Sriram Shanmugavelandy



Education and Lab Experience:

  • Research Assistant, St. Louis University Department of Biochemistry and Molecular Biology (2013-2014)
  • Research Technologist II: Penn State College of Medicine: Hershey, 2008-2013
  • Senior Research Fellow: Central Leather Research Institute, Chennai 2007-2008
  • Project Assistant: National Brain Research Centre, Manesar, 2003-2005
  • Project Assistant: Jahawaharlal Nehru Center for Advance Scientific Research, Bangalore, 2001-2003


  • C6-ceramide nanoliposomes target the warburg effect in chronic lymphocytic leukemia.Ryland LK, Doshi UA,   Shanmugavelandy   SS , Fox TE, Aliaga C, Broeg K, Baab KT, Young M, Khan O, Haakenson JK, Jarbadan NR, Liao J, Wang HG, Feith DJ, Loughran TP Jr, Liu X, Kester M. PLoS One . 2013 Dec 19;8(12):e84648 .  
  • Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models.Adiseshaiah PP, Clogston JD, McLeland CB, Rodriguez J, Potter TM, Neun BW, Skoczen SL, Shanmugavelandy   SS , Kester M, Stern ST, McNeil SE. Cancer Lett . 2013 Sep 1;337(2):254-65.  
  • Gaucher's Disease and Cancer: A Sphingolipid Perspective. Barth BM, Shanmugavelandy SS , Tacelosky DM, Kester M, Morad SA, Cabot MC. Crit Rev Oncog . 2013;18(3):221-34
  • PhotoImmunoNanoTherapy Reveals an Anticancer Role for Sphingosine Kinase 2 and Dihydrosphingosine-1-Phosphate.Barth BM, Shanmugavelandy SS , Kaiser JM, McGovern C, Altinoglu EI, Haakenson JK, Hengst JA, Gilius EL, Knupp SA, Fox TE, Smith JP, Ritty TM, Adair JH, Kester M. ACS Nano . 2013 Feb 14.
  • Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53.Morad SA, Madigan JP, Levin JC, Abdelmageed N, Karimi R, Rosenberg DW, Kester M, Shanmugavelandy SS , Cabot MC.Biochem Pharmacol. 2013 Apr 15;85(8):1057-65
  • Targeting glucosylceramide synthase synergizes with C(6)-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia. Watters RJ, Fox TE, Tan SF ,   Shanmugavelandy SS , Choby JE, Broeg K, Liao J, Kester M, Cabot MC, Loughran TP, Liu X. Leuk Lymphoma . 2012 Dec 31
  • Ceramide--antiestrogen nanoliposomal combinations--novel impact of hormonal therapy in hormone-insensitive breast cancer. Morad SA, Levin JC, Shanmugavelandy SS , Kester M, Fabrias G, Bedia C, Cabot MC. Mol Cancer Ther . 2012 Nov;11(11):2352-61
  • Calcium phosphosilicate nanoparticles for imaging and photodynamic therapy of cancer.. Tacelosky DM, Creecy AE, Shanmugavelandy SS , Smith JP, Claxton DF, Adair JH, Kester M, Barth BM. Discov Med . 2012 Apr;13(71):275-85. Review.
  • Nanoliposomal minocycline for ocular drug delivery.Kaiser JM, Imai H, Haakenson JK, Brucklacher RM, Fox TE, Shanmugavelandy SS , Unrath KA, Pedersen MM, Dai P, Freeman WM, Bronson SK, Gardner TW, Kester M.
  • Nanomedicine . 2013 Jan;9(1):130-40
  • Combinatorial Therapies Improve the Therapeutic Efficacy of Nanoliposomal Ceramide for Pancreatic Cancer. Yixing Jiang Nicole A. DiVittore, James M. Kaise, Sriram S. Shanmugavelandy ,Jennifer L. Fritz, Yasser Heakal, Hephzibah Rani S. Tagaram,Hua Cheng, Myles C. Cabot, Melissa A. Tran, Todd E. Fox, Brian M. Barth, and Mark Kester, Cancer Biology and Therapy 2011 Oct 1;12(7):574-85
  • Targeted Indocyanine Green-Loaded Calcium Phosphosilicate Nanoparticles for In Vivo Photodynamic Therapy of Leukemia.Barth BM, Altinoglu EI, Sriram.S.Shanmugavelandy , Kaiser JM, Crespo-Gonzalez D, Divittore NA, McGovern C, Goff TM, Keasey NR, Adair JH, Loughran TP, Claxton DF, Kester M. ACS Nano . 2011 Jun 15. [Epub ahead of print]
  • Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance. Barth BM, Gustafson SJ, Young MM, Fox TE, Sriram.S.Shanmugavelandy , Kaiser JM, Cabot MC, Kester M, Kuhn TB. Cancer Biol Ther . 2010 Dec 1;10(11):1126-36.
  • Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia. Liu X, Ryland L, Yang J, Liao A, Aliaga C, Watts R, Tan SF, Kaiser J, Sriram S. Shanmugavelandy , Rogers A, Loughran K, Petersen B, Yuen J, Meng F, Baab KT, Jarbadan NR, Broeg K, Zhang R, Liao J, Sayers TJ, Kester M, Loughran TP Jr. Blood . 2010 Aug 3.
  • Bioconjugation of calcium phosphosilicate composite nanoparticles for selective targeting of human breast and pancreatic cancers in vivo.Barth BM, Sharma R, Altinoglu EI, Morgan TT, Sriram S. Shanmugavelandy , Kaiser JM, McGovern C, Matters GL, Smith JP, Kester M, Adair JH. ACS Nano . 2010 Mar 23;4(3):1279-87
  • Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU.Kline CL, Sriram S. Shanmugavelandy , Kester M, Irby RB. Cancer Biol Ther . 2009 Oct;8(19):1831-7.
  • Encapsulation of Organic Molecules in Calcium Phosphate Nanocomposite Particles for Intracellular Imaging and Drug Delivery. Thomas T. Morgan, 1 Hari S. Muddana, 2 Erhan I. Altinoglu, 1 Sarah M. Rouse, 1 Amra Tabakovic, 1 Tristan Tabouillot, 2 Timothy J. Russin, 3 Sriram S. Shanmugavelandy , 4 Peter J. Butler, 2 Peter C. Eklund, 3 Jong K. Yun, 4 Mark Kester, 4 and James H. Adair 1. Nano Lett . 2008 Dec;8(12):4108-15.
  • Identification of Wuchereria bancrofti from blood smears using PCR. Saravanan SS , Hoti SL, Kannan S. BioChem Cell Arch 2002:2(Vol. 1&2):57-61.