Publications

He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG and Jiang H. NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes. (2018) Cell Metab.. 27, 1055-1066.e3 Pubmed Cell Metab. PMC Article
Duerr MA, Palladino END, Hartman CL, Lambert JA, Franke JD, Albert CJ, Matalon S, Patel RP, Slungaard A and Ford DA. Bromofatty aldehyde derived from bromine exposure and myeloperoxidase and eosinophil peroxidase modify GSH and protein. (2018) J. Lipid Res.. 59, 696-705 Pubmed J. Lipid Res. PMC Article
Palladino END, Hartman CL, Albert CJ and Ford DA. The chlorinated lipidome originating from myeloperoxidase-derived HOCl targeting plasmalogens: Metabolism, clearance, and biological properties. (2018) Arch. Biochem. Biophys.. 641, 31-38 Pubmed Arch. Biochem. Biophys. PMC Article
Yu H, Wang M, Wang D, Kalogeris TJ, McHowat J, Ford DA and Korthuis RJ. Chlorinated Lipids Elicit Inflammatory Responses In Vitro and In Vivo. (2018) Shock. Pubmed Shock
Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Martín MG, Alrefai WA, Ford DA and Tontonoz P. Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. (2018) Cell Stem Cell. 22, 206-220.e4 Pubmed Cell Stem Cell PMC Article
Hartman CL, Duerr MA, Albert CJ, Neumann WL, McHowat J and Ford DA. 2-Chlorofatty acids induce Weibel-Palade body mobilization. (2018) J. Lipid Res.. 59, 113-122 Pubmed J. Lipid Res. PMC Article
Meyer NJ, Reilly JP, Feng R, Christie JD, Hazen SL, Albert CJ, Franke JD, Hartman CL, McHowat J and Ford DA. Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome. (2017) JCI Insight. 2, Pubmed JCI Insight PMC Article
Rong X, Wang B, Palladino EN, de Aguiar Vallim TQ, Ford DA and Tontonoz P. ER phospholipid composition modulates lipogenesis during feeding and in obesity. (2017) J. Clin. Invest.. 127, 3640-3651 Pubmed J. Clin. Invest. PMC Article
Price NL, Rotllan N, Canfrán-Duque A, Zhang X, Pati P, Arias N, Moen J, Mayr M, Ford DA, Baldán Á, Suárez Y and Fernández-Hernando C. Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis. (2017) Cell Rep. 21, 1317-1330 Pubmed Cell Rep PMC Article
Lambert JA, Carlisle MA, Lam A, Aggarwal S, Doran S, Ren C, Bradley WE, Dell'Italia L, Ambalavanan N, Ford DA, Patel RP, Jilling T and Matalon S. Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant Mice. (2017) Hypertension. 70, 390-400 Pubmed Hypertension PMC Article
de Aguiar Vallim TQ, Lee E, Merriott DJ, Goulbourne CN, Cheng J, Cheng A, Gonen A, Allen RM, Palladino END, Ford DA, Wang T, Baldán Á and Tarling EJ. ABCG1 regulates pulmonary surfactant metabolism in mice and men. (2017) J. Lipid Res.. 58, 941-954 Pubmed J. Lipid Res. PMC Article
Palladino EN, Wang WY, Albert CJ, Langhi C, Baldán Á and Ford DA. Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism. (2017) J. Lipid Res.. 58, 317-324 Pubmed J. Lipid Res. PMC Article
Pike DP, Hartman CL, Weissler GJ, Palladino EN, Albert CJ and Ford DA. Platelet-Activating Factor Quantification Using Reversed Phase Liquid Chromatography and Selected Reaction Monitoring in Negative Ion Mode. (2016) Lipids. 51, 1421-1425 Pubmed Lipids PMC Article
Ford DA, Honavar J, Albert CJ, Duerr MA, Oh JY, Doran S, Matalon S and Patel RP. Formation of chlorinated lipids post-chlorine gas exposure. (2016) J. Lipid Res.. 57, 1529-40 Pubmed J. Lipid Res. PMC Article
Pauta M, Rotllan N, Fernández-Hernando A, Langhi C, Ribera J, Lu M, Boix L, Bruix J, Jimenez W, Suárez Y, Ford DA, Baldán A, Birnbaum MJ, Morales-Ruiz M and Fernández-Hernando C. Akt-mediated foxo1 inhibition is required for liver regeneration. (2016) Hepatology. 63, 1660-74 Pubmed Hepatology PMC Article
Wang B, Rong X, Duerr MA, Hermanson DJ, Hedde PN, Wong JS, Vallim TQ, Cravatt BF, Gratton E, Ford DA and Tontonoz P. Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. (2016) Cell Metab.. 23, 492-504 Pubmed Cell Metab. PMC Article
Aroor AR, Habibi J, Ford DA, Nistala R, Lastra G, Manrique C, Dunham MM, Ford KD, Thyfault JP, Parks EJ, Sowers JR and Rector RS. Dipeptidyl peptidase-4 inhibition ameliorates Western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. (2015) Diabetes. 64, 1988-2001 Pubmed Diabetes PMC Article
Duerr MA, Aurora R and Ford DA. Identification of glutathione adducts of α-chlorofatty aldehydes produced in activated neutrophils. (2015) J. Lipid Res.. 56, 1014-24 Pubmed J. Lipid Res. PMC Article
Shih DM, Yu JM, Vergnes L, Dali-Youcef N, Champion MD, Devarajan A, Zhang P, Castellani LW, Brindley DN, Jamey C, Auwerx J, Reddy ST, Ford DA, Reue K and Lusis AJ. PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. (2015) FASEB J.. 29, 1185-97 Pubmed FASEB J. PMC Article
Rong X, Wang B, Dunham MM, Hedde PN, Wong JS, Gratton E, Young SG, Ford DA and Tontonoz P. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. (2015) Elife. 4, Pubmed Elife PMC Article
Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL and Tarling EJ. ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. (2014) J. Immunol.. 193, 5637-48 Pubmed J. Immunol. PMC Article
Soufi N, Hall AM, Chen Z, Yoshino J, Collier SL, Mathews JC, Brunt EM, Albert CJ, Graham MJ, Ford DA and Finck BN. Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. (2014) J. Biol. Chem.. 289, 30177-88 Pubmed J. Biol. Chem. PMC Article
Mahieu MA, Guild CP, Albert CJ, Kondos GT, Carr JJ, Edmundowicz D, Ford DA and Ramsey-Goldman R. Alpha-chlorofatty Acid and coronary artery or aorta calcium scores in women with systemic lupus erythematosus. A pilot study. (2014) J. Rheumatol.. 41, 1834-42 Pubmed J. Rheumatol. PMC Article
Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA and Brown RJ. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. (2014) Lipids. 49, 505-15 Pubmed Lipids PMC Article
Shao F and Ford DA. Elaidic acid increases hepatic lipogenesis by mediating sterol regulatory element binding protein-1c activity in HuH-7 cells. (2014) Lipids. 49, 403-13 Pubmed Lipids PMC Article
Wang WY, Albert CJ and Ford DA. Alpha-chlorofatty acid accumulates in activated monocytes and causes apoptosis through reactive oxygen species production and endoplasmic reticulum stress. (2014) Arterioscler. Thromb. Vasc. Biol.. 34, 526-32 Pubmed Arterioscler. Thromb. Vasc. Biol. PMC Article
Wang WY, Albert CJ and Ford DA. Approaches for the analysis of chlorinated lipids. (2013) Anal. Biochem.. 443, 148-52 Pubmed Anal. Biochem. PMC Article
Essaji Y, Yang Y, Albert CJ, Ford DA and Brown RJ. Hydrolysis products generated by lipoprotein lipase and endothelial lipase differentially impact THP-1 macrophage cell signalling pathways. (2013) Lipids. 48, 769-778 Pubmed Lipids PMC Article
Shao F and Ford DA. Differential regulation of ABCA1 and macrophage cholesterol efflux by elaidic and oleic acids. (2013) Lipids. 48, 757-67 Pubmed Lipids PMC Article
Wacker BK, Albert CJ, Ford BA and Ford DA. Strategies for the analysis of chlorinated lipids in biological systems. (2013) Free Radic. Biol. Med.. 59, 92-9 Pubmed Free Radic. Biol. Med. PMC Article
Brown RJ, Shao F, Baldán A, Albert CJ and Ford DA. Cholesterol efflux analyses using stable isotopes and mass spectrometry. (2013) Anal. Biochem.. 433, 56-64 Pubmed Anal. Biochem. PMC Article
Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ, Ananthanarayanan M, Ford DA and Baldán A. miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity. (2012) EMBO Mol Med. 4, 882-95 Pubmed EMBO Mol Med PMC Article
Bowden JA, Shao F, Albert CJ, Lally JW, Brown RJ, Procknow JD, Stephenson AH and Ford DA. Electrospray ionization tandem mass spectrometry of sodiated adducts of cholesteryl esters. (2011) Lipids. 46, 1169-79 Pubmed Lipids PMC Article
Bowden JA, Albert CJ, Barnaby OS and Ford DA. Analysis of cholesteryl esters and diacylglycerols using lithiated adducts and electrospray ionization-tandem mass spectrometry. (2011) Anal. Biochem.. 417, 202-10 Pubmed Anal. Biochem. PMC Article
Bowden JA and Ford DA. An examination of pentafluorobenzoyl derivatization strategies for the analysis of fatty alcohols using gas chromatography/electron capture negative ion chemical ionization-mass spectrometry. (2011) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.. 879, 1375-83 Pubmed J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. PMC Article
Ford DA. Lipid oxidation by hypochlorous acid: chlorinated lipids in atherosclerosis and myocardial ischemia. (2010) Clin Lipidol. 5, 835-852 Pubmed Clin Lipidol PMC Article
Brahmbhatt VV, Albert CJ, Anbukumar DS, Cunningham BA, Neumann WL and Ford DA. {Omega}-oxidation of {alpha}-chlorinated fatty acids: identification of {alpha}-chlorinated dicarboxylic acids. (2010) J. Biol. Chem.. 285, 41255-69 Pubmed J. Biol. Chem. PMC Article
Anbukumar DS, Shornick LP, Albert CJ, Steward MM, Zoeller RA, Neumann WL and Ford DA. Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal. (2010) J. Lipid Res.. 51, 1085-92 Pubmed J. Lipid Res. PMC Article
Albert CJ, Anbukumar DS, Messner MC and Ford DA. Chromatographic methods for the analyses of 2-halofatty aldehydes and chlorohydrin molecular species of lysophosphatidylcholine. (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.. 877, 2768-77 Pubmed J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. PMC Article
Lankalapalli RS, Eckelkamp JT, Sircar D, Ford DA, Subbaiah PV and Bittman R. Synthesis and antioxidant properties of an unnatural plasmalogen analogue bearing a trans O-vinyl ether linkage. (2009) Org. Lett.. 11, 2784-7 Pubmed Org. Lett. PMC Article
Messner MC, Albert CJ and Ford DA. 2-Chlorohexadecanal and 2-chlorohexadecanoic acid induce COX-2 expression in human coronary artery endothelial cells. (2008) Lipids. 43, 581-8 Pubmed Lipids PMC Article
Ford DA, Monda JK, Brush RS, Anderson RE, Richards MJ and Fliesler SJ. Lipidomic analysis of the retina in a rat model of Smith-Lemli-Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species. (2008) J. Neurochem.. 105, 1032-47 Pubmed J. Neurochem. PMC Article
Brahmbhatt VV, Nold C, Albert CJ and Ford DA. Quantification of pentafluorobenzyl oxime derivatives of long chain aldehydes by GC-MS analysis. (2008) Lipids. 43, 275-80 Pubmed Lipids PMC Article
Messner MC, Albert CJ, McHowat J and Ford DA. Identification of lysophosphatidylcholine-chlorohydrin in human atherosclerotic lesions. (2008) Lipids. 43, 243-9 Pubmed Lipids PMC Article
Brahmbhatt VV, Hsu FF, Kao JL, Frank EC and Ford DA. Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. (2007) Chem. Phys. Lipids. 145, 72-84 Pubmed Chem. Phys. Lipids
Albert CJ, Anbukumar DS, Monda JK, Eckelkamp JT and Ford DA. Myocardial lipidomics. Developments in myocardial nuclear lipidomics. (2007) Front. Biosci.. 12, 2750-60 Pubmed Front. Biosci. PMC Article
Chandrasekaran S, Deffenbaugh AE, Ford DA, Bailly E, Mathias N and Skowyra D. Destabilization of binding to cofactors and SCFMet30 is the rate-limiting regulatory step in degradation of polyubiquitinated Met4. (2006) Mol. Cell. 24, 689-699 Pubmed Mol. Cell
Messner MC, Albert CJ, Hsu FF and Ford DA. Selective plasmenylcholine oxidation by hypochlorous acid: formation of lysophosphatidylcholine chlorohydrins. (2006) Chem. Phys. Lipids. 144, 34-44 Pubmed Chem. Phys. Lipids
Wildsmith KR, Albert CJ, Anbukumar DS and Ford DA. Metabolism of myeloperoxidase-derived 2-chlorohexadecanal. (2006) J. Biol. Chem.. 281, 16849-60 Pubmed J. Biol. Chem.
Wildsmith KR, Albert CJ, Hsu FF, Kao JL and Ford DA. Myeloperoxidase-derived 2-chlorohexadecanal forms Schiff bases with primary amines of ethanolamine glycerophospholipids and lysine. (2006) Chem. Phys. Lipids. 139, 157-70 Pubmed Chem. Phys. Lipids
Thukkani AK, Martinson BD, Albert CJ, Vogler GA and Ford DA. Neutrophil-mediated accumulation of 2-ClHDA during myocardial infarction: 2-ClHDA-mediated myocardial injury. (2005) Am. J. Physiol. Heart Circ. Physiol.. 288, H2955-64 Pubmed Am. J. Physiol. Heart Circ. Physiol.
Thukkani AK, McHowat J, Hsu FF, Brennan ML, Hazen SL and Ford DA. Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic lesions. (2003) Circulation. 108, 3128-33 Pubmed Circulation
Thukkani AK, Albert CJ, Wildsmith KR, Messner MC, Martinson BD, Hsu FF and Ford DA. Myeloperoxidase-derived reactive chlorinating species from human monocytes target plasmalogens in low density lipoprotein. (2003) J. Biol. Chem.. 278, 36365-72 Pubmed J. Biol. Chem.
Martinson BD, Albert CJ, Corbett JA, Wysolmerski RB and Ford DA. Calcium-independent phospholipase A2 mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells. (2003) J. Lipid Res.. 44, 1686-91 Pubmed J. Lipid Res.
Albert CJ, Thukkani AK, Heuertz RM, Slungaard A, Hazen SL and Ford DA. Eosinophil peroxidase-derived reactive brominating species target the vinyl ether bond of plasmalogens generating a novel chemoattractant, alpha-bromo fatty aldehyde. (2003) J. Biol. Chem.. 278, 8942-50 Pubmed J. Biol. Chem.
Ford DA. Separate myocardial ethanolamine phosphotransferase activities responsible for plasmenylethanolamine and phosphatidylethanolamine synthesis. (2003) J. Lipid Res.. 44, 554-9 Pubmed J. Lipid Res.
Steer SA, Wirsig KC, Creer MH, Ford DA and McHowat J. Regulation of membrane-associated iPLA2 activity by a novel PKC isoform in ventricular myocytes. (2002) Am. J. Physiol., Cell Physiol.. 283, C1621-6 Pubmed Am. J. Physiol., Cell Physiol.
Maggi LB, Moran JM, Scarim AL, Ford DA, Yoon JW, McHowat J, Buller RM and Corbett JA. Novel role for calcium-independent phospholipase A(2) in the macrophage antiviral response of inducible nitric-oxide synthase expression. (2002) J. Biol. Chem.. 277, 38449-55 Pubmed J. Biol. Chem.
Thukkani AK, Hsu FF, Crowley JR, Wysolmerski RB, Albert CJ and Ford DA. Reactive chlorinating species produced during neutrophil activation target tissue plasmalogens: production of the chemoattractant, 2-chlorohexadecanal. (2002) J. Biol. Chem.. 277, 3842-9 Pubmed J. Biol. Chem.
Albert CJ, Crowley JR, Hsu FF, Thukkani AK and Ford DA. Reactive brominating species produced by myeloperoxidase target the vinyl ether bond of plasmalogens: disparate utilization of sodium halides in the production of alpha-halo fatty aldehydes. (2002) J. Biol. Chem.. 277, 4694-703 Pubmed J. Biol. Chem.
Ford DA. Alterations in myocardial lipid metabolism during myocardial ischemia and reperfusion. (2002) Prog. Lipid Res.. 41, 6-26 Pubmed Prog. Lipid Res.
Williams SD and Ford DA. Calcium-independent phospholipase A(2) mediates CREB phosphorylation and c-fos expression during ischemia. (2001) Am. J. Physiol. Heart Circ. Physiol.. 281, H168-76 Pubmed Am. J. Physiol. Heart Circ. Physiol.
Albert CJ, Crowley JR, Hsu FF, Thukkani AK and Ford DA. Reactive chlorinating species produced by myeloperoxidase target the vinyl ether bond of plasmalogens: identification of 2-chlorohexadecanal. (2001) J. Biol. Chem.. 276, 23733-41 Pubmed J. Biol. Chem.
Williams SD, Hsu FF and Ford DA. Electrospray ionization mass spectrometry analyses of nuclear membrane phospholipid loss after reperfusion of ischemic myocardium. (2000) J. Lipid Res.. 41, 1585-95 Pubmed J. Lipid Res.
Albert CJ and Ford DA. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. (1999) Am. J. Physiol.. 276, H642-50 Pubmed Am. J. Physiol.
Albert CJ and Ford DA. Identification of specific nuclear protein kinase C isozymes and accelerated protein kinase C-dependent nuclear protein phosphorylation during myocardial ischemia. (1998) FEBS Lett.. 438, 32-6 Pubmed FEBS Lett.
Ford DA, Horner CC and Gross RW. Protein kinase C acylation by palmitoyl coenzyme A facilitates its translocation to membranes. (1998) Biochemistry. 37, 11953-61 Pubmed Biochemistry
Hale CC, Ebeling EG, Hsu FF and Ford DA. The selective activation of the cardiac sarcolemmal sodium-calcium exchanger by plasmalogenic phosphatidic acid produced by phospholipase D. (1998) FEBS Lett.. 422, 247-51 Pubmed FEBS Lett.
Williams SD and Ford DA. Activation of myocardial cAMP-dependent protein kinase by lysoplasmenylcholine. (1997) FEBS Lett.. 420, 33-8 Pubmed FEBS Lett.
Ford DA and Hale CC. Plasmalogen and anionic phospholipid dependence of the cardiac sarcolemmal sodium-calcium exchanger. (1996) FEBS Lett.. 394, 99-102 Pubmed FEBS Lett.
Hazen SL, Ford DA and Gross RW. Activation of a membrane-associated phospholipase A2 during rabbit myocardial ischemia which is highly selective for plasmalogen substrate. (1991) J. Biol. Chem.. 266, 5629-33 Pubmed J. Biol. Chem.
Ford DA and Gross RW. Differential metabolism of diradyl glycerol molecular subclasses and molecular species by rabbit brain diglyceride kinase. (1990) J. Biol. Chem.. 265, 12280-6 Pubmed J. Biol. Chem.
Ford DA and Gross RW. Activation of myocardial protein kinase C by plasmalogenic diglycerides. (1990) Am. J. Physiol.. 258, C30-6 Pubmed Am. J. Physiol.
Balogun KA, Albert CJ, Ford DA, Brown RJ and Cheema SK. Dietary omega-3 polyunsaturated fatty acids alter the fatty acid composition of hepatic and plasma bioactive lipids in C57BL/6 mice: a lipidomic approach. (2013) PLoS ONE. 8, e82399 Pubmed PLoS ONE PMC Article