We study the mechanism of recombination mediator proteins (RMPs) using structural methods combined with biophysical and biochemical approaches. RMPs are important for genome stability in all organisms. They regulate chromosome breaks repair, restart of stalled replication and many other DNA metabolism pathways.  Mutations of human RMPs lead to cancer predisposition. In pathogens, RMPs are involved in adaptation to stress , immune response and drug resistance.

Additional projects include structural studies of

  1. -calcium-independent phospholipase, implicated in cardiovascular diseases, diabetes and neurodegeneration;

  2. -ubiquitin ligase regulation by membrane-anchored ubiquitin-fold protein (with Dr. B. Downes);

  3. -HIV integrase (with D. Grandgenett);

  4. -HBV RNase H (with J. Tavis). 

Contacts:

Office: (314) 977-9261

Lab: (314) 977-9262

Fax: (314) 977-9205

E-mail: korolevs@slu.edu


Mailing Address:

1100 South Grand Boulevard

Doisy Research Center

Korolev Lab, Room 555

Saint Louis, MO 63104


Shipping Address:

1205 Carr Lane

Doisy Research Center

Korolev Lab, Room 555

Saint Louis, MO 63104