Angel Baldan, Ph.D., Associate Professor, and his research group, Ananthi Rajamoorthi, M.D./Ph.D. student, and Noemi Arias, Ph.D., Postdoctoral Fellow, were featured in Newslink in December 2016 regarding a paper-in-press in the Journal of Lipid Research. The paper details studies on the effects of a protein found in liver and fat tissue on blood sugar and body fat levels in a mouse model of obesity.
The protein in mice, fat-specific protein 27 or Fsp27, promotes intracellular lipid storage. Complete loss has been shown to have deleterious consequences. The Baldan group instead tested partial silencing using antisense oligonucleotides added to different diets fed to obese mice. The partial silencing resulted in a marked decrease in visceral fat and better insulin sensitivity, as well as other positive blood sugar and lipid changes. Their studies could lead to new therapeutic treatments for obese and insulin-insensitive patients.