Several Biochemistry investigators were recently awarded Multi-PI grants. These types of collaborative applications have a good record of being funded and could be a new way for investigators to obtain grant awards.
Dale Dorsett, Ph.D., Susana Gonzalo, Ph.D., and Alessandro Vindigni, Ph.D., received a Siteman Cancer Center Investment Program Pre-R01 grant entitled “DNA replication, nuclear architecture, and genome stability.” Their projects aim at understanding how cells replicate accurately and then using this information to produce improved and more selective chemotherapy agents for the treatment of cancer. The proposal was funded for two years and will hoepfully result in a Program Project application to the National Cancer Institute.
David Ford, Ph.D., received a multi-PI, multi-center grant from the NIGMS entitled “Chlorinated lipids in sepsis.” Jane McHowat, Ph.D., of the Department of Pathology at SLU, is a Co-PI on the grant. Other investigators on the proposal include Thomas Cho, Ph.D., of the Department of Biochemistry at SLU, and Ron Korthuis, Ph.D., of the Department of of Medical Pharmacology and Physiology at the University of Missouri-Columbia School of Medicine.
The research will focus on determining the role of chlorinated lipids in vascular collapse and multiorgan failure during sepsis. These lipids are produced when leukocytes are activated following development of sepsis and can lead to endothelial dysfunction, platelet activation, and organ damage.