Mee-Ngan F. Yap, Ph.D., published her recent findings on hibernating ribosomes in Staphylococcus aureus in a second high-profile journal. Her article in Nature Communications details her studies on 100S ribosomes in two different bacterial species.
Staph bacteria constantly contain hibernating 100S ribosomes, while E. coli bacteria mainly form 100S ribosomes under stressful or nutrient poor conditions. In staph, only one protein factor, HPF, is needed to form the 100S ribosome and the complex is assembled differently than in E. coli. These findings may indicate possible targets for treatment of staph and other Gram-positive bacteria.
Overall structure of the SA100S ribosome dimer.