Yuna Ayala, Ph.D.

Yuna Ayala, Ph.D.
Assistant Professor

Studies on RNA binding protein function in eukaryotic mRNA processing and neurodegenerative diseases.

Office: DRC 523
Voice: (314) 977-9247

Research Interests

The regulation of pre-mRNA processing, critical in the control of gene function and often linked to human disease, is mediated through the interaction between mRNA and protein partners. The TAR DNA binding protein (TDP-43) is an essential RNA binding protein whose dysfunction and aggregation are tightly associated with neurodegenerative disorders, i.e., amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, and frontotemporal dementia (FTLD). We investigate the cellular function and molecular structure of RNA binding proteins, such as TDP-43, to understand basic mechanisms of RNA processing and pathogenesis.

Recent Publications

Department of Biochemistry and Molecular Biology