Yuna Ayala, Ph.D.

Yuna Ayala, Ph.D.
Assistant Professor

Studies on RNA binding protein function in eukaryotic mRNA processing and neurodegenerative diseases.

Office: DRC 523
Voice: (314) 977-9247

Research Interests

The regulation of pre-mRNA processing, critical in the control of gene function and often linked to human disease, is mediated through the interaction between mRNA and protein partners. The TAR DNA binding protein (TDP-43) is an essential RNA binding protein whose dysfunction and aggregation are tightly associated with neurodegenerative disorders, i.e., amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, and frontotemporal dementia (FTLD). We investigate the cellular function and molecular structure of RNA binding proteins, such as TDP-43, to understand basic mechanisms of RNA processing and pathogenesis.

Recent Publications

Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function
Li W, Reeb AN, Lin B, Subramanian P, Fey EE, Knoverek CR, French RL, Bigio EH and Ayala YM

TDP-43 regulates its mRNA levels through a negative feedback loop
Ayala YM, De Conti L, Avendaño-Vázquez SE, Dhir A, Romano M, D’Ambrogio A, Tollervey J, Ule J, Baralle M, Buratti E and Baralle FE

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo
D’Ambrogio A, Buratti E, Stuani C, Guarnaccia C, Romano M, Ayala YM and Baralle FE

Structural determinants of the cellular localization and shuttling of TDP-43
Ayala YM, Zago P, D’Ambrogio A, Xu YF, Petrucelli L, Buratti E and Baralle FE

Improving human interferon-beta production in mammalian cell lines by insertion of an intronic sequence within its naturally uninterrupted gene
Zago P, Baralle M, Ayala YM, Skoko N, Zacchigna S, Buratti E and Tisminetzky S

Department of Biochemistry and Molecular Biology