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Yie-Hwa Chang, Ph.D.
Associate Professor

Understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino terminal processing of eukaryotic proteins and its role in angiogenesis.

Office: DRC 515
Voice: (314) 977-9263

Research Interests

Our lab is interested in understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino-terminal processing of eukaryotic proteins and its role in angiogenesis. Recently, the type-2 MetAP was found to be the molecular target for angiogenesis inhibitors, TNP-470 and ovalicin. Angiogenesis is the process of new blood vessel formation. It plays very important roles in both physiological states and a variety of pathological states.

Recent Publications

Elderly Woman With Fever and Abdominal Discomfort
Lin CH, Lu CH and Chang YH

Synergistic cardioprotective effects of rAAV9-CyclinA2 combined with fibrin glue in rats after myocardial infarction
Cao W, Chang YF, Zhao AC, Chen BD, Liu F, Ma YT and Ma X

Role of PARL-PINK1-Parkin pathway in adipocyte differentiation
Shiau MY, Lee PS, Huang YJ, Yang CP, Hsiao CW, Chang KY, Chen HW and Chang YH

PET/MRI for evaluating subclinical inflammation of ulcerative colitis
Shih IL, Wei SC, Yen RF, Chang CC, Ko CL, Lin BR, Shun CT, Liu KL, Wong JM and Chang YC

Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer
Jung JY, Kim EY, Kim A, Chang J, Kwon NH, Moon Y, Kang EJ, Sung JS, Shim H, Kim S and Chang YS

Department of Biochemistry and Molecular Biology
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