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Yie-Hwa Chang, Ph.D.
Associate Professor

Understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino terminal processing of eukaryotic proteins and its role in angiogenesis.

Office: DRC 515
Voice: (314) 977-9263

Research Interests

Our lab is interested in understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino-terminal processing of eukaryotic proteins and its role in angiogenesis. Recently, the type-2 MetAP was found to be the molecular target for angiogenesis inhibitors, TNP-470 and ovalicin. Angiogenesis is the process of new blood vessel formation. It plays very important roles in both physiological states and a variety of pathological states.

Recent Publications

Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes
Basu A, Saito K, Meyer K, Ray RB, Friedman SL, Chang YH and Ray R

Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes, and risk factors
Metheny NA, Clouse RE, Chang YH, Stewart BJ, Oliver DA and Kollef MH

N-terminal methionine removal and methionine metabolism in Saccharomyces cerevisiae
Dummitt B, Micka WS and Chang YH

Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae
Dummitt B, Fei Y and Chang YH

A dominant negative mutation in Saccharomyces cerevisiae methionine aminopeptidase-1 affects catalysis and interferes with the function of methionine aminopeptidase-2
Klinkenberg M, Ling C and Chang YH

Department of Biochemistry and Molecular Biology
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