Enrico Di Cera, M.D.
Alice A. Doisy Professor and Chairman

Structure, function and regulation of trypsin-like proteases and their zymogens, protein engineering, and allostery.

Office: DRC 533
Voice: (314) 977-9201

Research Interests

We are interested in the structure, function and engineering of trypsin-like proteases and their zymogen forms. The main focus of the lab is on thrombin and prothrombin as key components of the blood coagulation system. Our experimental approach includes kinetics, thermodynamics, site-directed mutagenesis, X-ray structural biology and single molecule spectroscopy.

Recent Publications

Department of Biochemistry and Molecular Biology