Enrico Di Cera, M.D.
Alice A. Doisy Professor and Chairman

Structure, function and regulation of trypsin-like proteases and their zymogens, protein engineering, and allostery.

Office: DRC 533
Voice: (314) 977-9201

Research Interests

We are interested in the structure, function and engineering of trypsin-like proteases and their zymogen forms. The main focus of the lab is on thrombin and prothrombin as key components of the blood coagulation system. Our experimental approach includes kinetics, thermodynamics, site-directed mutagenesis, X-ray structural biology and single molecule spectroscopy.

Recent Publications

Induced Fit Is a Special Case of Conformational Selection
Chakraborty P and Di Cera E

Rational Design of Protein C Activators
Barranco-Medina S, Murphy M, Pelc L, Chen Z, Di Cera E and Pozzi N

Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity
Eickhoff CS, Zhang X, Vasconcelos JR, Motz RG, Sullivan NL, O’Shea K, Pozzi N, Gohara DW, Blase JR, Di Cera E and Hoft DF

Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence
Gillrie MR, Renaux B, Russell-Goldman E, Avril M, Brazier AJ, Mihara K, Di Cera E, Milner DA, Hollenberg MD, Smith JD and Ho M

Molecular Mechanisms of Enzyme Activation by Monovalent Cations
Gohara DW and Di Cera E

Department of Biochemistry and Molecular Biology