M.D., Ph.D., 1992, Shanghai Second Medical University, China
Research Interests
We are interested in the molecular and genetic mechanisms of cholesterol homeostasis and the pathophysiology of cholesterol-related diseases. Our current research focuses on the pathophysiology of cholesterol gallstone disease and genetic analysis of gallstone (Lith) genes, the molecular physiology and genetics of the intestinal cholesterol and fatty acid absorption, the biochemistry of bile formation, and the physical-chemistry of cholesterol crystallization in bile. Also, our research is directed principally at a specific area that appears to be fundamental to understanding nonalcoholic fatty liver disease, insulin resistance, and the metabolic syndrome.
Recent Publications
  • The dangerous link between childhood and adulthood predictors of obesity and metabolic syndrome.
    Faience MF, Wang DQ, et al. Intern Emerg Med. (2016) Jan 12 [Epub ahead of print].
  • The cholecystokinin-1 receptor antagonist devazepide increases cholesterol cholelithogenesis in mice.
    Wang HH, Portincasa P, Wang DQ. Eur J Clin Invest. (2016) 46(2):158-169.
  • Lack of endogenous cholecystokinin promotes cholelithogenesis in mice.
    Wang HH, Liu M, et al. Neurogastroenterol Motil. (2016) 28(3):364-375.
  • Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats.
    Zhang LS, Sato H, et al. Am J Physiol Gastrointest Liver Physiol. (2015) 309(11):G918-925.
  • Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats.
    Shen L, Wang DQ, et al. Physical Behav. (2015) 152(Pt A):62-67.
  • Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats.
    Shen L, Haas M, et al. Physiol Rep. (2015) 3(9):e12543.
  • The deletion of the estrogen receptor α gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice.
    de Bari O, Wang HH, et al. Biochim Biophys Acta. (2015) 1852(10 Pt A):2161-2169.
  • Estrogen induces two distinct cholesterol crystallization pathways by activating ERα and GPR30 in female mice.
    de Bari O, Wang TY, et al. J Lipid Res. (2015) 56(9):1691-1700.
  • Endogenous elevation of plasma cholecystokinin does not prevent gallstones.
    Shahid RA, Wang DQ, et al. Eur J Clin Invest. (2015) 45(3):237-246.
  • A novel therapeutic effect of statins on nephrogenic diabetes insipidus.
    Bonfrate L, Porcine G, et al. J Cell Mol Med. (2015) 19(2):265-282.