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Tomasz Heyduk, Ph.D.
Professor

Mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging.

Office: DRC 425
Voice: (314) 977-9238

Research Interests

Our lab has two major research interests: mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging. Our interest in transcription regulation is to understand the mechanism of transcription initiation by bacterial and archaeal RNA polymerases. Our primary focus in sensor research is to develop robust highly specific and sensitive molecular sensors that could be utilized in research, medical diagnosis and pathogen detection.

Recent Publications

RNA polymerase motions during promoter melting
Feklistov A, Bae B, Hauver J, Lass-Napiorkowska A, Kalesse M, Glaus F, Altmann KH, Heyduk T, Landick R and Darst SA

Real-Time Observation of Backtracking by Bacterial RNA Polymerase
Lass-Napiorkowska A and Heyduk T

Next Generation Sequencing-based analysis of RNA polymerase functions
Heyduk T and Heyduk E

Ribosome display enhanced by next generation sequencing: a tool to identify antibody-specific peptide ligands
Heyduk E and Heyduk T

Kinetics of promoter escape by bacterial RNA polymerase: effects of promoter contacts and transcription bubble collapse
Ko J and Heyduk T

Department of Biochemistry and Molecular Biology
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