Nicola Pozzi, Ph.D.

Nicola Pozzi, Ph.D.
Assistant Professor

Molecular mechanisms of thrombosis and immunothrombosis.

Office: DRC 511
Voice: (314) 977-9257

Research Interests

In our laboratory, we strive to understand the pathophysiological mechanisms that lead to thrombosis and immunothrombosis, an innate immune response that links coagulation to the recognition, containment and destruction of microbial pathogens. To achieve our goals, we apply a unique combination of biochemistry, protein engineering, X-ray crystallography, single molecule fluorescence biophysics (smFRET and FCS) and surface plasmon resonance (SPR).

Recent Publications

Rational Design of Protein C Activators
Barranco-Medina S, Murphy M, Pelc L, Chen Z, Di Cera E and Pozzi N

Molecular mapping of α-thrombin (αT)/β2-glycoprotein I (β2GpI) interaction reveals how β2GpI affects αT functions
Acquasaliente L, Peterle D, Tescari S, Pozzi N, Pengo V and De Filippis V

Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity
Eickhoff CS, Zhang X, Vasconcelos JR, Motz RG, Sullivan NL, O’Shea K, Pozzi N, Gohara DW, Blase JR, Di Cera E and Hoft DF

Structural Architecture of Prothrombin in Solution Revealed by Single Molecule Spectroscopy
Pozzi N, Bystranowska D, Zuo X and Di Cera E

Dual effect of histone H4 on prothrombin activation
Pozzi N and Di Cera E

Department of Biochemistry and Molecular Biology