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James Shoemaker, M.D.
Associate Professor

Screening children for inborn errors of metabolism using gas chromatography-mass spectrometry and evaluation of special nutritional needs in children with Down's syndrome.

Office: DRC 431
Voice: (314) 977-9230

Research Interests

Our clinical activities include screening for inborn errors of metabolism in children by quantifying chemicals in body fluids by gas chromatography-mass spectrometry. We developed a new method of sample preparation which allows carbohydrates and amino and organic acids to be detected in the same sample. Our current research is concerned with the evaluation of special nutritional needs in children with Down syndrome and the diagnosis of vitamin deficiency by quantitation of urinary metabolites after an oral dose of amino acids and other food constituents.

Recent Publications

Dicarboxylic Acid Excretion in Normal Formula-Fed and Breastfed Infants
Anderson M, Eliot K, Kelly P and Shoemaker J

Estimation of glucose utilization in a type 2 diabetes mellitus patient on insulin analogs with tumor hypoglycemia induced by IGF-II
Chode S, Albert SG, Shoemaker JD and Green AL

Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism
Shah GN, Rubbelke TS, Hendin J, Nguyen H, Waheed A, Shoemaker JD and Sly WS

One-step metabolomics: carbohydrates, organic and amino acids quantified in a single procedure
Shoemaker JD

Involvement of lipids in ferriprotoporphyrin IX polymerization in malaria
Fitch CD, Cai GZ, Chen YF and Shoemaker JD

Department of Biochemistry and Molecular Biology
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