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Dorota Skowyra, Ph.D.
Associate Professor

Studies on the role, function, and regulation of the ubiquitin-proteasome system in health and disease.

Office: DRC 507
Voice: (314) 977-9280

Research Interests

We are broadly interested in the role, function and regulation of the ubiquitin-proteasome system. Our former projects focused on the mechanism by which proteins are recruited for degradation by the 26S proteasome in yeast. We have recently initiated three new research directions that focus on the role of proteasomal proteolysis in 1) autoimmune diseases (type 1 diabetes); 2) protein misfolding diseases (liver disease associated with alpha 1 antitrypsin deficiency); and early antiviral responses (ectromelia virus/primary mouse macrophages). Biochemical and cellular approaches are our primary research tools.

Recent Publications

Erratum to: The loop-less ™Cdc34 E2 mutant defective polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2
Lass A, Cocklin R, Scaglione KM, Skowyra M, Korolev S, Goebl M and Skowyra D

PiZ mouse liver accumulates polyubiquitin conjugates that associate with catalytically active 26S proteasomes
Haddock CJ, Blomenkamp K, Gautam M, James J, Mielcarska J, Gogol E, Teckman J and Skowyra D

Immunoproteasome Activation During Early Antiviral Response in Mouse Pancreatic β-cells: New Insights into Auto-antigen Generation in Type I Diabetes?
Freudenburg W, Gautam M, Chakraborty P, James J, Richards J, Salvatori AS, Baldwin A, Schriewer J, Buller RM, Corbett JA and Skowyra D

Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells
Freudenburg W, Gautam M, Chakraborty P, James J, Richards J, Salvatori AS, Baldwin A, Schriewer J, Buller RM, Corbett JA and Skowyra D

The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2
Lass A, Cocklin R, Scaglione KM, Skowyra M, Korolev S, Goebl M and Skowyra D

Department of Biochemistry and Molecular Biology
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