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We are still working on this page. Tools will be added and opened gradually until the end of August, the date of the first complete version of this web site. You can find more about the schedule in "what's next ?"
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Catalog
Knock-out
 
 
+/-(Seq-Fun)
+/-(Seq-Fun)
+/-(Struc-Tree-Fun)
+/-(Seq-Struc-Tree-Fun)
Cor(Seq-Fun)
Cor(Seq-Fun)
Cor(Struc-Tree-Fun)
Cor(Seq-Struc-Tree-Fun)
 

Click the orange button in the menu above or the orange bullet in the descriptive menu below. A Red bullet means the corresponding page is not yet released. If you click on it you will find an estimate of the release date and its current state of development.

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Function catalogs

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1
An nice catalog is already available at the MEROPS web site as Biomedical and Biotechnological Aspects of Peptidases (menu: catalog )
Physiologic function description and pharmacologic target. Companies need a license to use this facility from Rawlings N.D.
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2
Knock out gene references (menu: knock-out)
Description of end developmental stage if lethal.
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Sequence-function correlation

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1
Qualitative description of the specified function (menu: +/-(seq-fun))
Input: Set of sequence accession numbers and associated function (+/-)
Output: amino acid properties best-correlated for each position and list of positions to copy and paste
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2
Quantitative description of the function as qualitative (menu: +/-(seq-fun))
Input: Set of sequence accession numbers and associated function
Output: amino acid properties best-correlated for each position
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3

Quantitative description of the function (menu: cor(seq-fun))
Input: Set of sequence accession numbers and associated function
Output: amino acid properties best-correlated for each position, cor.factor

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Structure-function correlation

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1
Qualitative description of the specified function (menu: +/-(struc-fun))
Input: Set of PDB/sequence accession numbers and associated function (+/-)
Output: amino acid parameters best-correlated for each position
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2
Quantitative description of the function as qualitative (menu: +/-(struc-fun))
Input: Set of PDB/sequence accession numbers and associated function
Output: amino acid parameters best-correlated for each position
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3

Quantitative description of the specified function (menu: cor(struc-fun))
Input: Set of PDB/sequence accession numbers and associated function
Output: amino acid parameters best-correlated for each position

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Evolution-function correlation

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1
Qualitative description of the specified function (menu: +/-(evol-fun) )
Input: Set of sequence accession numbers and associated function (+/-)
Output:
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Quantitative description of the function as qualitative (menu: +/-(evol-fun))
Input: Set of sequence accession numbers and associated function
Output:
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3

Quantitative description of the specified function (menu: cor(evol-fun))
Input: Set of sequence accession numbers and associated function
Output:

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(Sequence/Structure/Evolution) - function correlation

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1

Qualitative description of the specified function (menu: +/-(seq-stru-evol-fun))
Input: specified position, specified properties and associated function (+/-)
Output: 3D graphs

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2

Quantitative description of the function as qualitative (menu: +/-(seq-stru-evol-fun))
Input: PDB accession numbers, chain identifiers, domain of superposed pair and compared pair
Output: 3D graphs

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3

Quantitative description of the specified function (menu: cor(seq-stru-evol-fun))
Input: PDB accession numbers, chain identifiers, domain of superimposed pair and compared pair
Output: 3D graphs

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Go to the Washington University in St Louis
Go to the School of MedicineGo to the Department of Biochemistry and Molecular Biophysics


Thierry Rose, PhD and Enrico Di Cera, MD
Department of Biochemistry and Molecular Biophysics
Washington University School of Medicine
Saint Louis, MO, U.S.A.

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