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Tour

Very soon a tour of the tools proposed through this web site will be available here, later this week .

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Tutorials

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Lesson 1 : Extract residues involved in the active site specificity of trypsin by comparison to chymotrypsin
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1
Selection of residues common to trypsin and not to chymotrypsin
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2
Selection of residues common to trypsin and not to chymotrypsin
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Selection of residues accessible to substrate and close to the active site
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Display the residues on the accessible surface
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Lesson 2: Define the common feature of the Ca binding site in serine protease
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Selection of serine proteases which bind Ca ion in the 70-80 domain.
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Selection of sequences with more than 10% of identity with the proteins of the Ca binding sequence-set.
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Looking for correlation between Ca-binding function and amino acid properties of the two sequence sets
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Display the residues on the accessible surface
  horiz_blue.gifLesson 3: Define the concensus sequence of the clotting factors in the evolutionary tree built with Dist/Fitch
release Select residues as identical in the chosen clotting factor branch, as similar in the other clotting factor branches and as differenr in the others.
release Make a set with the selected residues and filter the ones close to the active site
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Go to the Washington University in St Louis
Go to the School of MedicineGo to the Department of Biochemistry and Molecular Biophysics


Thierry Rose, PhD and Enrico Di Cera, MD
Department of Biochemistry and Molecular Biophysics
Washington University School of Medicine
Saint Louis, MO, U.S.A.

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