Publications

Ayala YM and Grese ZR. Finding a chaperone for TDP-43. (2022) Nat Cell Biol. 24, 1328-1330 Pubmed Nat Cell Biol
Grese ZR, Bastos AC, Mamede LD, French RL, Miller TM and Ayala YM. Specific RNA interactions promote TDP-43 multivalent phase separation and maintain liquid properties. (2021) EMBO Rep. 22, e53632 Pubmed EMBO Rep PMC Article
Wood M, Quinet A, Lin YL, Davis AA, Pasero P, Ayala YM and Vindigni A. TDP-43 dysfunction results in R-loop accumulation and DNA replication defects. (2020) J Cell Sci. 133, Pubmed J Cell Sci PMC Article
Conicella AE, Dignon GL, Zerze GH, Schmidt HB, D'Ordine AM, Kim YC, Rohatgi R, Ayala YM, Mittal J and Fawzi NL. TDP-43 α-helical structure tunes liquid-liquid phase separation and function. (2020) Proc Natl Acad Sci U S A. 117, 5883-5894 Pubmed Proc Natl Acad Sci U S A PMC Article
French RL, Grese ZR, Aligireddy H, Dhavale DD, Reeb AN, Kedia N, Kotzbauer PT, Bieschke J and Ayala YM. Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation. (2019) J Biol Chem. 294, 6696-6709 Pubmed J Biol Chem PMC Article
Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM and Fawzi NL. A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. (2018) EMBO J. 37, Pubmed EMBO J PMC Article
Li W, Reeb AN, Lin B, Subramanian P, Fey EE, Knoverek CR, French RL, Bigio EH and Ayala YM. Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function. (2017) J Biol Chem. 292, 5089-5100 Pubmed J Biol Chem PMC Article
Ayala YM, De Conti L, Avendaño-Vázquez SE, Dhir A, Romano M, D'Ambrogio A, Tollervey J, Ule J, Baralle M, Buratti E and Baralle FE. TDP-43 regulates its mRNA levels through a negative feedback loop. (2011) EMBO J. 30, 277-88 Pubmed EMBO J PMC Article
D'Ambrogio A, Buratti E, Stuani C, Guarnaccia C, Romano M, Ayala YM and Baralle FE. Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo. (2009) Nucleic Acids Res. 37, 4116-26 Pubmed Nucleic Acids Res PMC Article
Zago P, Baralle M, Ayala YM, Skoko N, Zacchigna S, Buratti E and Tisminetzky S. Improving human interferon-beta production in mammalian cell lines by insertion of an intronic sequence within its naturally uninterrupted gene. (2009) Biotechnol Appl Biochem. 52, 191-8 Pubmed Biotechnol Appl Biochem
Ayala YM, Zago P, D'Ambrogio A, Xu YF, Petrucelli L, Buratti E and Baralle FE. Structural determinants of the cellular localization and shuttling of TDP-43. (2008) J Cell Sci. 121, 3778-85 Pubmed J Cell Sci
Ayala YM, Misteli T and Baralle FE. TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression. (2008) Proc Natl Acad Sci U S A. 105, 3785-9 Pubmed Proc Natl Acad Sci U S A PMC Article
Ayala YM, Pagani F and Baralle FE. TDP43 depletion rescues aberrant CFTR exon 9 skipping. (2006) FEBS Lett. 580, 1339-44 Pubmed FEBS Lett
Buratti E, Brindisi A, Giombi M, Tisminetzky S, Ayala YM and Baralle FE. TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. (2005) J Biol Chem. 280, 37572-84 Pubmed J Biol Chem
Ayala YM, Pantano S, D'Ambrogio A, Buratti E, Brindisi A, Marchetti C, Romano M and Baralle FE. Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function. (2005) J Mol Biol. 348, 575-88 Pubmed J Mol Biol
Romano M, Marcucci R, Buratti E, Ayala YM, Sebastio G and Baralle FE. Regulation of 3' splice site selection in the 844ins68 polymorphism of the cystathionine Beta -synthase gene. (2002) J Biol Chem. 277, 43821-9 Pubmed J Biol Chem
Ayala YM, Cantwell AM, Rose T, Bush LA, Arosio D and Di Cera E. Molecular mapping of thrombin-receptor interactions. (2001) Proteins. 45, 107-16 Pubmed Proteins
Ayala YM and Di Cera E. A simple method for the determination of individual rate constants for substrate hydrolysis by serine proteases. (2000) Protein Sci. 9, 1589-93 Pubmed Protein Sci PMC Article
Arosio D, Ayala YM and Di Cera E. Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR-1 or protein C. (2000) Biochemistry. 39, 8095-101 Pubmed Biochemistry
Vindigni A, Winfield M, Ayala YM and Di Cera E. Role of residue Y99 in tissue plasminogen activator. (2000) Protein Sci. 9, 619-22 Pubmed Protein Sci PMC Article
Di Cera E, Dang QD and Ayala YM. Molecular mechanisms of thrombin function. (1997) Cell Mol Life Sci. 53, 701-30 Pubmed Cell Mol Life Sci
Véscovi EG, Ayala YM, Di Cera E and Groisman EA. Characterization of the bacterial sensor protein PhoQ. Evidence for distinct binding sites for Mg2+ and Ca2+. (1997) J Biol Chem. 272, 1440-3 Pubmed J Biol Chem
Sullivan DJ, Ayala YM and Goldberg DE. An unexpected 5' untranslated intron in the P. falciparum genes for histidine-rich proteins II and III. (1996) Mol Biochem Parasitol. 83, 247-51 Pubmed Mol Biochem Parasitol
Guinto ER, Vindigni A, Ayala YM, Dang QD and Di Cera E. Identification of residues linked to the slow-->fast transition of thrombin. (1995) Proc Natl Acad Sci U S A. 92, 11185-9 Pubmed Proc Natl Acad Sci U S A PMC Article
Ayala YM, Vindigni A, Nayal M, Spolar RS, Record MT and Di Cera E. Thermodynamic investigation of hirudin binding to the slow and fast forms of thrombin: evidence for folding transitions in the inhibitor and protease coupled to binding. (1995) J Mol Biol. 253, 787-98 Pubmed J Mol Biol
Di Cera E, Guinto ER, Vindigni A, Dang QD, Ayala YM, Wuyi M and Tulinsky A. The Na+ binding site of thrombin. (1995) J Biol Chem. 270, 22089-92 Pubmed J Biol Chem
Mercado PA, Ayala YM, Romano M, Buratti E and Baralle FE. Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene. (2005) Nucleic Acids Res. 33, 6000-10 Pubmed Nucleic Acids Res PMC Article
Ayala YM and Nguyen AD. RNA-Based Therapies for Neurodegenerative Diseases. (2021) Mo Med. 118, 340-345 Pubmed Mo Med PMC Article
Buratti E, Baralle M, De Conti L, Baralle D, Romano M, Ayala YM and Baralle FE. hnRNP H binding at the 5' splice site correlates with the pathological effect of two intronic mutations in the NF-1 and TSHbeta genes. (2004) Nucleic Acids Res. 32, 4224-36 Pubmed Nucleic Acids Res PMC Article
Koehler LC, Grese ZR, Bastos ACS, Mamede LD, Heyduk T and Ayala YM. TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation. (2022) Front Neurosci. 16, 818655 Pubmed Front Neurosci PMC Article
Ayala YM, Arosio D and Di Cera E. Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR1 or protein C. (2001) Ann N Y Acad Sci. 936, 456-8 Pubmed Ann N Y Acad Sci