The Di Cera Lab recently published a plenary paper in Blood entitled “Cryo-EM structure of the prothrombin-prothrombinase complex.” The paper details the spatial arrangement of the structure of the prothrombin-fXa-fVa complex for the first time and offers a molecular view of prothrombin activation along the meizothrombin pathway.

Researchers used Cryo-EM to solve the structures of the fVa-fXa complex, one free on nanodiscs and the other bound to prothrombin.