Carolyn Albert

Education and Lab Experience:

  • Supervisor, Biochemistry and Molecular Biology Metabolomics Facility (2004-present)
  • Research Lab Supervisor, Saint Louis University Department of Biochemistry and Molecular Biology (2013-present)
  • Senior Research Assistant, Saint Louis University Department of Biochemistry and Molecular Biology, Ford laboratory (1998-2013)
  • Research Assistant, Saint Louis University Department of Biochemistry and Molecular Biology, Ford laboratory (1996-1998)
  • Research Assistant, Saint Louis University Department of Biochemistry and Molecular Biology, William Longmore laboratory (1991-1996)
  • B.A. in Biology, Illinois Wesleyan University, Bloomington, IL (1990)

Publications:

Shim SH, Sur S, Steele R, Albert CJ, Huang C, Ford DA and Ray RB. Disrupting cholesterol esterification by bitter melon suppresses triple-negative breast cancer cell growth. (2018) Mol. Carcinog.. 57, 1599-1607 Pubmed Mol. Carcinog.
Duerr MA, Palladino END, Hartman CL, Lambert JA, Franke JD, Albert CJ, Matalon S, Patel RP, Slungaard A and Ford DA. Bromofatty aldehyde derived from bromine exposure and myeloperoxidase and eosinophil peroxidase modify GSH and protein. (2018) J. Lipid Res.. 59, 696-705 Pubmed J. Lipid Res. PMC Article
Palladino END, Hartman CL, Albert CJ and Ford DA. The chlorinated lipidome originating from myeloperoxidase-derived HOCl targeting plasmalogens: Metabolism, clearance, and biological properties. (2018) Arch. Biochem. Biophys.. 641, 31-38 Pubmed Arch. Biochem. Biophys. PMC Article
Hartman CL, Duerr MA, Albert CJ, Neumann WL, McHowat J and Ford DA. 2-Chlorofatty acids induce Weibel-Palade body mobilization. (2018) J. Lipid Res.. 59, 113-122 Pubmed J. Lipid Res. PMC Article
Meyer NJ, Reilly JP, Feng R, Christie JD, Hazen SL, Albert CJ, Franke JD, Hartman CL, McHowat J and Ford DA. Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome. (2017) JCI Insight. 2, Pubmed JCI Insight PMC Article
Palladino EN, Wang WY, Albert CJ, Langhi C, Baldán Á and Ford DA. Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism. (2017) J. Lipid Res.. 58, 317-324 Pubmed J. Lipid Res. PMC Article
Pike DP, Hartman CL, Weissler GJ, Palladino EN, Albert CJ and Ford DA. Platelet-Activating Factor Quantification Using Reversed Phase Liquid Chromatography and Selected Reaction Monitoring in Negative Ion Mode. (2016) Lipids. 51, 1421-1425 Pubmed Lipids PMC Article
Ford DA, Honavar J, Albert CJ, Duerr MA, Oh JY, Doran S, Matalon S and Patel RP. Formation of chlorinated lipids post-chlorine gas exposure. (2016) J. Lipid Res.. 57, 1529-40 Pubmed J. Lipid Res. PMC Article
Soufi N, Hall AM, Chen Z, Yoshino J, Collier SL, Mathews JC, Brunt EM, Albert CJ, Graham MJ, Ford DA and Finck BN. Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. (2014) J. Biol. Chem.. 289, 30177-88 Pubmed J. Biol. Chem. PMC Article
Mahieu MA, Guild CP, Albert CJ, Kondos GT, Carr JJ, Edmundowicz D, Ford DA and Ramsey-Goldman R. Alpha-chlorofatty Acid and coronary artery or aorta calcium scores in women with systemic lupus erythematosus. A pilot study. (2014) J. Rheumatol.. 41, 1834-42 Pubmed J. Rheumatol. PMC Article
Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA and Brown RJ. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. (2014) Lipids. 49, 505-15 Pubmed Lipids PMC Article
Wang WY, Albert CJ and Ford DA. Alpha-chlorofatty acid accumulates in activated monocytes and causes apoptosis through reactive oxygen species production and endoplasmic reticulum stress. (2014) Arterioscler. Thromb. Vasc. Biol.. 34, 526-32 Pubmed Arterioscler. Thromb. Vasc. Biol. PMC Article
Wang WY, Albert CJ and Ford DA. Approaches for the analysis of chlorinated lipids. (2013) Anal. Biochem.. 443, 148-52 Pubmed Anal. Biochem. PMC Article
Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA and Tontonoz P. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. (2013) Cell Metab.. 18, 685-97 Pubmed Cell Metab. PMC Article
Essaji Y, Yang Y, Albert CJ, Ford DA and Brown RJ. Hydrolysis products generated by lipoprotein lipase and endothelial lipase differentially impact THP-1 macrophage cell signalling pathways. (2013) Lipids. 48, 769-778 Pubmed Lipids PMC Article
Wacker BK, Albert CJ, Ford BA and Ford DA. Strategies for the analysis of chlorinated lipids in biological systems. (2013) Free Radic. Biol. Med.. 59, 92-9 Pubmed Free Radic. Biol. Med. PMC Article
Rubinow KB, Wall VZ, Nelson J, Mar D, Bomsztyk K, Askari B, Lai MA, Smith KD, Han MS, Vivekanandan-Giri A, Pennathur S, Albert CJ, Ford DA, Davis RJ and Bornfeldt KE. Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages. (2013) J. Biol. Chem.. 288, 9957-70 Pubmed J. Biol. Chem. PMC Article
Brown RJ, Shao F, Baldán A, Albert CJ and Ford DA. Cholesterol efflux analyses using stable isotopes and mass spectrometry. (2013) Anal. Biochem.. 433, 56-64 Pubmed Anal. Biochem. PMC Article
Demarco VG, Ford DA, Henriksen EJ, Aroor AR, Johnson MS, Habibi J, Ma L, Yang M, Albert CJ, Lally JW, Ford CA, Prasannarong M, Hayden MR, Whaley-Connell AT and Sowers JR. Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice. (2013) Endocrinology. 154, 159-71 Pubmed Endocrinology PMC Article
Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ, Ananthanarayanan M, Ford DA and Baldán A. miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity. (2012) EMBO Mol Med. 4, 882-95 Pubmed EMBO Mol Med PMC Article
Bowden JA, Shao F, Albert CJ, Lally JW, Brown RJ, Procknow JD, Stephenson AH and Ford DA. Electrospray ionization tandem mass spectrometry of sodiated adducts of cholesteryl esters. (2011) Lipids. 46, 1169-79 Pubmed Lipids PMC Article
Bowden JA, Albert CJ, Barnaby OS and Ford DA. Analysis of cholesteryl esters and diacylglycerols using lithiated adducts and electrospray ionization-tandem mass spectrometry. (2011) Anal. Biochem.. 417, 202-10 Pubmed Anal. Biochem. PMC Article
Brahmbhatt VV, Albert CJ, Anbukumar DS, Cunningham BA, Neumann WL and Ford DA. {Omega}-oxidation of {alpha}-chlorinated fatty acids: identification of {alpha}-chlorinated dicarboxylic acids. (2010) J. Biol. Chem.. 285, 41255-69 Pubmed J. Biol. Chem. PMC Article
Anbukumar DS, Shornick LP, Albert CJ, Steward MM, Zoeller RA, Neumann WL and Ford DA. Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal. (2010) J. Lipid Res.. 51, 1085-92 Pubmed J. Lipid Res. PMC Article
Albert CJ, Anbukumar DS, Messner MC and Ford DA. Chromatographic methods for the analyses of 2-halofatty aldehydes and chlorohydrin molecular species of lysophosphatidylcholine. (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.. 877, 2768-77 Pubmed J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. PMC Article
Messner MC, Albert CJ and Ford DA. 2-Chlorohexadecanal and 2-chlorohexadecanoic acid induce COX-2 expression in human coronary artery endothelial cells. (2008) Lipids. 43, 581-8 Pubmed Lipids PMC Article
Brahmbhatt VV, Nold C, Albert CJ and Ford DA. Quantification of pentafluorobenzyl oxime derivatives of long chain aldehydes by GC-MS analysis. (2008) Lipids. 43, 275-80 Pubmed Lipids PMC Article
Messner MC, Albert CJ, McHowat J and Ford DA. Identification of lysophosphatidylcholine-chlorohydrin in human atherosclerotic lesions. (2008) Lipids. 43, 243-9 Pubmed Lipids PMC Article
Albert CJ, Anbukumar DS, Monda JK, Eckelkamp JT and Ford DA. Myocardial lipidomics. Developments in myocardial nuclear lipidomics. (2007) Front. Biosci.. 12, 2750-60 Pubmed Front. Biosci. PMC Article
Messner MC, Albert CJ, Hsu FF and Ford DA. Selective plasmenylcholine oxidation by hypochlorous acid: formation of lysophosphatidylcholine chlorohydrins. (2006) Chem. Phys. Lipids. 144, 34-44 Pubmed Chem. Phys. Lipids
Wildsmith KR, Albert CJ, Anbukumar DS and Ford DA. Metabolism of myeloperoxidase-derived 2-chlorohexadecanal. (2006) J. Biol. Chem.. 281, 16849-60 Pubmed J. Biol. Chem.
Wildsmith KR, Albert CJ, Hsu FF, Kao JL and Ford DA. Myeloperoxidase-derived 2-chlorohexadecanal forms Schiff bases with primary amines of ethanolamine glycerophospholipids and lysine. (2006) Chem. Phys. Lipids. 139, 157-70 Pubmed Chem. Phys. Lipids
Thukkani AK, Martinson BD, Albert CJ, Vogler GA and Ford DA. Neutrophil-mediated accumulation of 2-ClHDA during myocardial infarction: 2-ClHDA-mediated myocardial injury. (2005) Am. J. Physiol. Heart Circ. Physiol.. 288, H2955-64 Pubmed Am. J. Physiol. Heart Circ. Physiol.
Martinson BD, Albert CJ, Corbett JA, Wysolmerski RB and Ford DA. Calcium-independent phospholipase A2 mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells. (2003) J. Lipid Res.. 44, 1686-91 Pubmed J. Lipid Res.
Thukkani AK, Albert CJ, Wildsmith KR, Messner MC, Martinson BD, Hsu FF and Ford DA. Myeloperoxidase-derived reactive chlorinating species from human monocytes target plasmalogens in low density lipoprotein. (2003) J. Biol. Chem.. 278, 36365-72 Pubmed J. Biol. Chem.
Albert CJ, Thukkani AK, Heuertz RM, Slungaard A, Hazen SL and Ford DA. Eosinophil peroxidase-derived reactive brominating species target the vinyl ether bond of plasmalogens generating a novel chemoattractant, alpha-bromo fatty aldehyde. (2003) J. Biol. Chem.. 278, 8942-50 Pubmed J. Biol. Chem.
Thukkani AK, Hsu FF, Crowley JR, Wysolmerski RB, Albert CJ and Ford DA. Reactive chlorinating species produced during neutrophil activation target tissue plasmalogens: production of the chemoattractant, 2-chlorohexadecanal. (2002) J. Biol. Chem.. 277, 3842-9 Pubmed J. Biol. Chem.
Albert CJ, Crowley JR, Hsu FF, Thukkani AK and Ford DA. Reactive brominating species produced by myeloperoxidase target the vinyl ether bond of plasmalogens: disparate utilization of sodium halides in the production of alpha-halo fatty aldehydes. (2002) J. Biol. Chem.. 277, 4694-703 Pubmed J. Biol. Chem.
Albert CJ, Crowley JR, Hsu FF, Thukkani AK and Ford DA. Reactive chlorinating species produced by myeloperoxidase target the vinyl ether bond of plasmalogens: identification of 2-chlorohexadecanal. (2001) J. Biol. Chem.. 276, 23733-41 Pubmed J. Biol. Chem.
Albert CJ and Ford DA. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. (1999) Am. J. Physiol.. 276, H642-50 Pubmed Am. J. Physiol.
Albert CJ and Ford DA. Identification of specific nuclear protein kinase C isozymes and accelerated protein kinase C-dependent nuclear protein phosphorylation during myocardial ischemia. (1998) FEBS Lett.. 438, 32-6 Pubmed FEBS Lett.
Balogun KA, Albert CJ, Ford DA, Brown RJ and Cheema SK. Dietary omega-3 polyunsaturated fatty acids alter the fatty acid composition of hepatic and plasma bioactive lipids in C57BL/6 mice: a lipidomic approach. (2013) PLoS ONE. 8, e82399 Pubmed PLoS ONE PMC Article