Principle Investigator

Photo of David Ford Ph.D.
David Ford, Ph.D.
Professor & Director of the Center for Cardiovascular Research Email: 314-977-9264

Education and Lab Experience:

  • Director of the Center for Cardiovascular Reseach, Saint Louis University (2008-present)
  • Professor, Saint Louis University (2005-present)
  • Associate Professor, Saint Louis University (2000-2005)
  • Assistant Professor, Saint Louis University (1996-2000)
  • Research Assistant Professor of Medicine, Washington University (1989-1996)
  • Research Instructor of Medicine, Washington University (1988-1989)
  • Research Fellow, Washington University (1987-1988)
  • Postdoctoral Research, Washington University (1985-1987)
  • Postdoctoral Research, University of Missouri-Columbia (1985)
  • Ph.D., University of Missouri-Columbia (1985)

Professional Societies and Awards:

  • American Society for Biochemistry and Molecular Biology
  • American Physiological Society
  • American Heart Association
  • Heart Failure Society of America
  • International Society of Heart Research
  • Society for Free Radical Biology and Medicine
  • American Chemical Society
  • American Society for Mass Spectrometry

Research Interests:

Our research focuses on discovering biochemical mechanisms that are responsible for the pathophysiological sequelae of human disease. We are examining changes that occur at the blood/blood vessel interface that is altered during sepsis, leading to multi-organ failure. The Ford lab has discovered molecules derived from activated leukocytes, including chlorinated lipids and reactive aldehyde-containing compounds. These novel molecules are being investigated as mediators of dysfunction at the blood/blood vessel interface. In particular, these molecules have important roles in activating endothelial cells and altering leukocyte function. In addition to the mechanistic roles of the lipids, we are also determining their potential as prognostic indicators of human sepsis outcomes. Other areas of interest include mechanisms involved in cardiovascular diseases. For these research programs we have employed a multidisciplinary, collaborative approach, including bio-organic (chemical synthesis and mass spectrometry) techniques, biochemical methods, physiological models, and translational/clinical validation.