Structural biology and single-molecule studies of Antiphospholipid Syndrome

Through a variety of state-of-the-art biochemical and biophysical methods, our lab studies the dynamic personalities of proteins involved in Antiphospholipid Syndrome, such as thiol-oxidoreductases, complement, and clotting factors. Our goals are to:

1) Visualize such proteins as they perform their physiological functions in real-time

2) Define how antiphospholipid antibodies alter these functions

We ultimately employ this knowledge of protein dynamics to design novel compounds or biologics to better treat and diagnose APS.

“All truths are easy to understand once they are discovered; the point is to discover them”  (Galileo Galilei) 

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