X-ray structures of human beta-2 glycoprotein I purified from human plasma (gray) and made recombinant in BHK (cyan) and HEK293 cells (magenta)(PDB ID: 6V06, 6V08, 6V09). Ruben et al., JBC 2020

Our research aims to advance fundamental understanding of hematological disorders and pave the way for safer, more effective treatments. Our lab’s logo reflects this mission through three key elements.

The IgG antibody represents our work on antiphospholipid antibodies and our commitment to improving the diagnosis and treatment of antiphospholipid syndrome (APS), a serious autoimmune condition that disrupts normal blood clotting.

The U-shaped protein structure (PDI) highlights our structure-based, mechanistic approach to studying disease. By exploring how proteins are built and behave, we seek to uncover new insights that can lead to more precise and targeted therapies.

The organic molecule symbolizes vitamin K. This essential nutrient plays a critical role in blood coagulation and was first isolated by Edward A. Doisy, the founder of our department and recipient of the Nobel Prize in Medicine in 1943. Its name comes from the German word “Koagulation,” reflecting its importance in clotting. Warfarin, a well-known vitamin K analogue, has helped millions of people, including those with APS. However, most current blood thinners have significant limitations. In this context, vitamin K represents both a historical milestone and our aspiration for a brighter future in anticoagulant therapy.