Selected publications since 2016

1. Chinnaraj M, Flaumenhaft R, Pozzi NReduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles. J Biol Chem. 2022 Jun 30;298(8):102217

 2. Chinnaraj M, Pengo V, Pozzi N. A Novel ELISA Assay for the Detection of Anti-Prothrombin Antibodies in Antiphospholipid Syndrome Patients at High Risk of Thrombosis.Front Immunol. 2021 Sep 8;12:741589.

3. Kumar S*, Chinnaraj M*, Planer W, Zuo X, Macor P, Tedesco F, Pozzi N. An allosteric redox switch in domain V of β2-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition. J Biol Chem. 2021 Aug;297(2):100890. (* equal contribution)

4. Chinnaraj M, Barrios DA, Frieden C, Heyduk T, Flaumenhaft R, Pozzi N. Bioorthogonal Chemistry Enables Single-Molecule FRET Measurements of Catalytically Active Protein Disulfide Isomerase.Chembiochem. 2021 Jan 5;22(1):134-138. 

5. Ruben E*, Planer W*, Chinnaraj M, Chen Z, Zuo X, Pengo V, De Filippis V, Alluri RK, McCrae KR, Macor P, Tedesco F, Pozzi N. The J-elongated conformation of β2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome. J Biol Chem. 2020 Jul 31;295(31):10794 (* equal contribution). 

6. Chinnaraj M, Planer W, Pengo V, Pozzi NDiscovery and characterization of 2 novel subpopulations of aPS/PT antibodies in patients at high risk of thrombosis. Blood Adv. 2019 Jun 11;3(11):1738-1749.

7. Chinnaraj M, Planer W, Pozzi NStructure of Coagulation Factor II: Molecular Mechanism of Thrombin Generation and Development of Next-Generation Anticoagulants. Front Med (Lausanne). 2018;5:281. 

8. Chinnaraj M, Chen Z, Pelc LA, Grese Z, Bystranowska D, Di Cera E, Pozzi NStructure of prothrombin in the closed form reveals new details on the mechanism of activation. Sci Rep. 2018 Feb 13;8(1):2945

9. Pozzi N, Bystranowska D, Zuo X, Di Cera E. Structural Architecture of Prothrombin in Solution Revealed by Single Molecule Spectroscopy. J Biol Chem. 2016 Aug 26;291(35):18107-16. 

All lab publications can be found in PubMed