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Overview

The Saint Louis University Genomics & Bioinformatics Core Facility provides state-of-the-art single-cell genomics and integrative bioinformatics services to both internal and external researchers. Utilizing advanced platforms like 10x Genomics for single-cell library preparation, we deliver high-resolution data to drive meaningful discovery across a wide range of biological questions.

Whether you’re new to genomics or an experienced researcher, our team is here to support your project from start to finish. We offer comprehensive services—from experimental design and library construction to data analysis and interpretation—making complex genomics research accessible, efficient, and impactful.

Publications from the Core

Hoft SG, Brennan M, Carrero JA, Jackson NM, Pretorius CA, Bigley TM, Sáenz JB and DiPaolo RJ. Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis. (2025) Gastroenterology. 168, 53-67 Pubmed Gastroenterology PMC Article
Brennan M, DeBruin D, Nwokolo C, Hunt KS, Piening A, Donlin MJ, Ferris ST, Teague RM, DiPaolo RJ and Alspach E. T-Cell Expression of CXCL13 is Associated with Immunotherapy Response in a Sex-Dependent Manner in Patients with Lung Cancer. (2024) Cancer Immunol Res. 12, 956-963 Pubmed Cancer Immunol Res
Sur S, Bhartiya P, Steele R, Brennan M, DiPaolo RJ and Ray RB. Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes. (2024) Mol Cancer Ther. 23, 672-682 Pubmed Mol Cancer Ther PMC Article
Piening A, Ebert E, Gottlieb C, Khojandi N, Kuehm LM, Hoft SG, Pyles KD, McCommis KS, DiPaolo RJ, Ferris ST, Alspach E and Teague RM. Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk. (2024) Nat Commun. 15, 2835 Pubmed Nat Commun PMC Article
Gisch DL, Brennan M, Lake BB, Basta J, Keller MS, Melo Ferreira R, Akilesh S, Ghag R, Lu C, Cheng YH, Collins KS, Parikh SV, Rovin BH, Robbins L, Stout L, Conklin KY, Diep D, Zhang B, Knoten A, Barwinska D, Asghari M, Sabo AR, Ferkowicz MJ, Sutton TA, Kelly KJ, De Boer IH, Rosas SE, Kiryluk K, Hodgin JB, Alakwaa F, Winfree S, Jefferson N, Türkmen A, Gaut JP, Gehlenborg N, Phillips CL, El-Achkar TM, Dagher PC, Hato T, Zhang K, Himmelfarb J, Kretzler M, Mollah S, , Jain S, Rauchman M and Eadon MT. The chromatin landscape of healthy and injured cell types in the human kidney. (2024) Nat Commun. 15, 433 Pubmed Nat Commun PMC Article
Coll-Bonfill N, Mahajan U, Shashkova EV, Lin CJ, Mecham RP and Gonzalo S. Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature. (2023) Geroscience. 45, 965-982 Pubmed Geroscience PMC Article
Khojandi N, Connelly L, Piening A, Hoft SG, Pherson M, Donlin MJ, DiPaolo RJ and Teague RM. Single-cell analysis of peripheral CD8 T cell responses in patients receiving checkpoint blockade immunotherapy for cancer. (2023) Cancer Immunol Immunother. 72, 397-408 Pubmed Cancer Immunol Immunother PMC Article
Noto CN, Hoft SG, Bockerstett KA, Jackson NM, Ford EL, Vest LS and DiPaolo RJ. IL13 Acts Directly on Gastric Epithelial Cells to Promote Metaplasia Development During Chronic Gastritis. (2022) Cell Mol Gastroenterol Hepatol. 13, 623-642 Pubmed Cell Mol Gastroenterol Hepatol PMC Article
Hoft SG, Pherson MD and DiPaolo RJ. Discovering Immune-Mediated Mechanisms of Gastric Carcinogenesis Through Single-Cell RNA Sequencing. (2022) Front Immunol. 13, 902017 Pubmed Front Immunol PMC Article