Alessandro Vindigni Awarded NCI Grant

Congratulations to Alessandro Vindigni for receiving a 5-year R01 grant from the National Cancer Institute. The grant, entitled “Replication fork repriming versus reversal,” will study the mechanisms that control DNA replication fork stability after treatment with multiple drug doses in BRCA-mutant tumors and how patients with BRCA gene mutations maintain their genome. The lab has identified the PrimPol-dependent repriming pathway, which is an important regulator of genome stability and which may influence senstitivity to DNA damaging chemotherapy in BRCA-mutant tumors.

Department of Biochemistry and Molecular Biology
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