David Ford, Ph.D., received a multi-PI, multi-center grant from the NIGMS entitled “Chlorinated lipids in sepsis.” Jane McHowat, Ph.D., of the Department of Pathology at SLU, is a Co-PI on the grant. Other investigators on the proposal include Thomas Cho, Ph.D., of the Department of Biochemistry, and Ron Korthuis, Ph.D., of the Department of of Medical Pharmacology and Physiology at the University of Missouri-Columbia School of Medicine.
The research will focus on determining the role of chlorinated lipids in vascular collapse and multiorgan failure during sepsis. These lipids are produced when leukocytes are activated following development of sepsis and can lead to endothelial dysfunction, platelet activation, and organ damage. They hope to find one or more biomarkers that can be used to determine when sepsis might develop, allowing for quicker diagnosis and treatment.
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