Vindigni Lab Discovers What Drives MRE11-Dependent Fork Slowing

The Vindigni Lab published a paper in Nucleic Acids Research entitled “Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing.” In collaboration with the Gonzalo Lab, the study details research on the role of Precocious Dissociation of Sister protein Pds5 isoforms in DNA replication. The researchers found that Pds5 is involved in replication fork progression during DNA replication and that loss of Pds5 leads to MRE11-dependent fork slowing through cohesin accumulation on replication forks.

Vindigni Nucleic Acids Res 2018 Fig 6D
Department of Biochemistry and Molecular Biology