Vindigni lab research may improve cancer treatment

Alessandro Vindigni, Ph.D., Associate Professor of Biochemistry, recently published new findings that could help to improve existing chemotherapy treatments for cancer patients. The study, published in Nature Structural and Molecular Biology on February 10, details their work on the role of RECQ1 helicase during replication stress response, particularly in tumor cells after anticancer drug treatment with DNA topoisomerase 1 inhibitors. This work challenges long-established models of how DNA replication deals with genotoxic stress and provides a new rationale for the design of novel targeted inhibitors to sensitize cancer cells to much lower doses of the selected chemotherapeutic agent that are not toxic to normal cells.

Department of Biochemistry and Molecular Biology