Yap Lab Studies Hibernating Ribosomes

Arnab Basu, Ph.D., and Mee-Ngan F. Yap, Ph.D., published their recent findings on hibernating ribosomes in Staphylococcus aureus in a second high-profile journal. The article in Nature Communications details Dr. Basu’s studies on 100S ribosomes in two different bacterial species.

Staph bacteria constantly contain hibernating 100S ribosomes, while E. coli bacteria mainly form 100S ribosomes under stressful or nutrient poor conditions. In staph, only one protein factor, HPF, is needed to form the 100S ribosome and the complex is assembled differently than in E. coli. These findings may indicate possible targets for treatment of staph and other Gram-positive bacteria.

This work is related to the Yap Lab’s recent publication in PNAS. You can read more details in Newslink.


Overall structure of the SA100S ribosome dimer.

Department of Biochemistry and Molecular Biology