Yap Lab Wakes Up Ribosomes

Arnab Basu, Ph.D., and Mee-Ngan F. Yap, Ph.D., have discovered how hibernating, or 100S, ribosomes are re-activated by the cell. Their findings were published in the Proceedings of the National Academy of Science USA.

Bacteria conserve energy under stressful conditions by hibernating ribosomes. The Yap Lab discovered that in Staphylococcus aureus, a GTP hydrolase enzyme, HflX, wakes up the ribosomes so they can return to the active 70S form. This pathway was previously unknown.

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A model summarizing the coregulation and opposing roles of HPF and HflX.

Department of Biochemistry and Molecular Biology