Enrico Di Cera, M.D.
Alice A. Doisy Professor and Chairman

Structural enzymology of coagulation factors.

Office: DRC 533
Voice: (314) 977-9201

Research Interests

We are interested in the interaction of prothrombin with prothrombinase leading to generation of thrombin and blood clotting, and the interaction of the thrombin-thrombomodulin complex with protein C initiating the negative feed-back loop that shuts down the coagulation response. Our experimental approach merges classical enzymology and X-ray structural biology with innovative techniques like smFRET, 19F NMR and Cryo-EM.

Recent Publications

Department of Biochemistry and Molecular Biology