pozzi nicola 2020-crop

Nicola Pozzi, Ph.D.
Associate Professor

Structure-function and single-molecule studies of oxidoreductases, complement, and clotting factors.

Office: DRC 403
Voice: (314) 977-9241

Research Interests

Through a variety of biochemical and biophysical methods, such as mutational analyses, enzyme kinetics, X-ray crystallography, single-molecule FRET, small-angle X-ray scattering, electron microscopy, and computer simulations, our lab studies the dynamic personalities of proteins. Our ultimate goal is to “visualize” proteins at atomic resolution in real-time as they perform their physiological function. We then employ this knowledge of protein dynamics for the design of novel compounds or biologics to treat or diagnose human disorders. One project explores the structure and function of protein co-factors, such as beta2-glycoprotein I (b2GPI) and prothrombin, that are targeted by antiphospholipid antibodies (aPL) in the systemic autoimmune disorder called Antiphospholipid Syndrome (APS). By revealing new, unexpected features of aPL autoantigens and the molecular mechanisms underlying antigen-antibody recognition in APS, our work may accelerate the development of innovative technologies to diagnose and treat APS patients. A second project in the lab elucidates the structure, function, and allosteric regulation of protein disulfide isomerases in thrombosis, cancer, and neurodegeneration.

Recent Publications

Department of Biochemistry and Molecular Biology