pozzi nicola 2020-crop

Nicola Pozzi, Ph.D.
Associate Professor & Secondary Associate Professor of Biomedical Engineering

Mechanisms of blood coagulation and Antiphospholipid Syndrome.

Office: DRC 403
Voice: (314) 977-9241

Research Interests

Our research focuses on the molecular mechanisms of thrombosis and hemostasis. We use biochemical and biophysical methods, like single-molecule fluorescence spectroscopy, protein engineering, non-canonical amino acids, cryo-EM, X-ray crystallography, and microfluidic technologies, to investigate how coagulation and complement factors operate and crosstalk during physiological conditions (i.e., hemostasis) and how their function is altered during pathological scenarios, leading to potentially life-threatening conditions like thrombosis (i.e., excessive formation of blood clots) and bleeding (i.e., inefficient formation of blood clots).
Basic knowledge inferred from these studies is used to explain patients’ clinical phenotypes, identify patients at higher risk of cardiovascular events and develop new strategies to restore hemostasis. While our approach is applicable to many disease states, most of our studies and research efforts are dedicated to advancing the diagnosis and treatment of Antiphospholipid Syndrome, a systemic autoimmune disorder resulting in life-threatening blood clots for which there is no cure.

Recent Publications

Department of Biochemistry and Molecular Biology