Biomaterial-based models are crucial for bridging the gap between traditional tissue culture and animal models by providing a cell environment that closely mimics real tissue. Novel biomaterials can be used as cell scaffolds, for drug screening platforms, to elucidate matrix structure-property relationships, and to assess cell-matrix interactions.

Dr. Zustiak also develops bioresorbable and injectable hydrogel and nanocomposite formulations as sustained release drug delivery devices. Her research is highly multidisciplinary, merging the fields of engineering, materials science, and biology.