Dorota Skowyra, Ph.D.
Associate Professor

Studies on the role, function, and regulation of the ubiquitin-proteasome system in health and disease.

Office: DRC 405
Voice: (314) 977-9280

Research Interests

I am interested in the mechanisms by which the ubiquitin-proteasome system (UPS) controls cellular functions in health and disease, as part of protein quality control (abnormal protein clearance, proteostasis, proteotoxicity) or signaling (cell growth & division, differentiation & life span progression, transcriptional regulation, generation of immunogenic peptides for MHC-I molecules). My independent research has initially focused on SCF, the founding member of Cullin-based E3 ubiquitin ligases. The subsequent clinically-related interests focus on the roles of UPS in type 1 diabetes onset, pediatric alpha1 liver disease, and FSHD muscular dystrophy. Each of these projects, while developed relatively recently, benefits from my long-term experience with analysis of: 1) protein ubiquitination, E3 ubiquitin ligases, and proteasome function and regulation; 2) molecular chaperones, protein folding and aggregation; and 3) diverse research models, from biochemical in vitro systems to organisms such as yeast, animals/mouse, and human cells. Multi-disciplinary approaches are the hallmark of my research.

Recent Publications

Department of Biochemistry and Molecular Biology