Studies on the role, function, and regulation of the ubiquitin-proteasome system in health and disease.
Office: DRC 205 Voice: (314) 977-9280
We are broadly interested in the role, function and regulation of the ubiquitin-proteasome system. Our former projects focused on the mechanism by which proteins are recruited for degradation by the 26S proteasome in yeast. We have recently initiated three new research directions that focus on the role of proteasomal proteolysis in 1) autoimmune diseases (type 1 diabetes); 2) protein misfolding diseases (liver disease associated with alpha 1 antitrypsin deficiency); and early antiviral responses (ectromelia virus/primary mouse macrophages). Biochemical and cellular approaches are our primary research tools.
Department of Biochemistry and Molecular Biology
Edward A. Doisy Research Center
Saint Louis University School of Medicine
1100 South Grand Blvd.
St. Louis, MO 63104