Dorota Skowyra, Ph.D.
Associate Professor

Studies on the role, function, and regulation of the ubiquitin-proteasome system in health and disease.

Office: DRC 405
Voice: (314) 977-9280

Research Interests

We are broadly interested in the role, function and regulation of the ubiquitin-proteasome system. Our former projects focused on the mechanism by which proteins are recruited for degradation by the 26S proteasome in yeast. We have recently initiated three new research directions that focus on the role of proteasomal proteolysis in 1) autoimmune diseases (type 1 diabetes); 2) protein misfolding diseases (liver disease associated with alpha 1 antitrypsin deficiency); and early antiviral responses (ectromelia virus/primary mouse macrophages). Biochemical and cellular approaches are our primary research tools.

Recent Publications

Department of Biochemistry and Molecular Biology