Serine Proteases: Mutations

We are still working on this page. Catalogs and tools will be added and opened gradually until the end of August, the date of the first complete version of this web site. You can find more about the schedule in "what's next ?"

	Thrombin	tPA	Trypsin	Chymotrypsin
	Position	Tolerance	Substitution-Function	Addition/Deletion-Function

Click the purple button in the menu above or the purple bullet in the descriptive menu below. A Red bullet means the corresponding page is not yet released. If you click on it you will find an estimate of the release date and its current state of development.

	Catalog Index

	Thrombin : list, effects, references
	Tissue Plasminogen Activator : list, effects, references
	Trypsin : list, effects, references
	Chymotrypsin : list, effects, references
	Factor X : list, effects, references
	Mutation Catalog by position (menu: position) Input: reference, position Output: mutations, references

	Mutation analyzer
	Position tolerance analyzer (menu:tolerance) Input: reference, position, set of accession numbers Output: tolerance to substitution, reference from indexed catalogs
	Correlation between functions and mutation effects (menu:substitution-function) Input: reference, position, substitution, quantitative function Output: correlation amino-acid properties/function
	Correlation between functions and mutation effects (menu:addition/deletion-function) Input: reference, position, insertion or deletion quantitative function Output: correlation added or lost amino-acid properties/function

[HomePage] [Sequence Index] [Sequence Analyser] [Mutations] [Evolution] [Tour-Tutorial] [Help]
[Structure Index] [Structure Analyzer] [Ligands] [Function][About] [Contact_us][Setup][Search] [Links]

Go to the Department of Biochemistry and Molecular Biophysics

Thierry Rose, PhD and Enrico Di Cera, MD
Department of Biochemistry and Molecular Biophysics
Washington University School of Medicine
Saint Louis, MO, U.S.A.