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Structure index description : S1
horiz_blue.gif
Legends  
p : o protein and organism names
AC accession number of the complete sequence used as reference
pdb pdb ids. Click to view the 3D structures from the linked PDB file (source is specified :X-ray, Nmr, Modeling, Homolog). Display with Chime (download, manual,tutorial) how to install it, how to use it.
Chains chains and molecules from the specified pdb file
AA seq residue position of the 3D structure from the sequence file as reference
Links links to databases through other sites
s=scop headers from the Protein Data Bank
c=cath Classification of the protein domain
p=procheck Procheck sumary report at UCL (UK)
r=rasmol,chime Display the molecule with Chime or Rasmol from UCL (UK)
v=VRML Display the molecule in a VRML browser from UCL (UK)
w=what if What If report at EMBL (D)
   
x original structure file from X-ray diffraction experiments , link to the PDB database at RCSB
xmc modified pdb file from X-ray data (no water, ions and ligand) keeping one chain of the catalytic domain to display in Chime
n original structure file from NMR diffraction experiments, link to the PDB database at RCSB
nmc modified pdb file from NMR data (no water, ions and ligand) keeping one chain of the catalytic domain to display in Chime
t theoritical model (detail of the modeling method in the file: ab initio, threading by homology)
tmc file modified (no water, ions and ligand) keeping one chain reduced to the catalytic domain to display in Chime
horiz_blue.gif
S1 family (scop, hssp, cath) Catalytic domain = Trypsin-fold, a/b= 2 orthogonal beta-barrels of 8 strands
Protein : organism

Sequence AC

PDB
Chains
Links
achelase I protease: giant silkworm moth, saturnid moth ACH1_LONAC
 
    
achelase II protease: giant silkworm moth, saturnid moth ACH2_LONAC
 
    
acrosin: goat ACRO_CAPHI
tmc:P10626
    
acrosin: human ACRO_HUMAN
tmc:P10323
    
acrosin: mouse ACRO_MOUSE
 
    
acrosin : pig ACRO_PIG
 
    
acrosin : rabbit ACRO_RABIT
 
    
acrosin: rat ACRO_RAT
 
    
ancrod: malayan pit viper ANC1_AGKRH
tmc:P26324
    
ancrod: malayan pit viper ANC2_AGKRH
 
    
ancrod: cantil, tropical mocassin ANCR_AGKBI
 
    
ancrod: southern copperhead ANCR_AGKCO
 
    
apolipoprotein(A): human APOA_HUMAN
tmc:P08519
    
apolipoprotein(A): rhesus macaque APOA_MACMU
 
    
batroxobin: barba amaril, fer-de-lance BATX_BOTAT
tmc:P04971
    
complement C1R component: human C1R_HUMAN
tmc:P00736
    
complement C1S component: human C1S_HUMAN
tmc:P09871
    
proproteinase E (procarboxypeptidaseA complex: bovine CAC3_BOVIN
xmc:1FON
x:1fon
x:1pyt
a+b
a+b
a+b+Ca+Zn+c

s, c, p, v, r, w
s, c, p, v, r, w
azurocidin(cathionic antimicrobial protein) : human CAP7_HUMAN
tmc:P20160
    
azurocidin(cathionic antimicrobial protein CAP37) : pig CAP7_PIG
 
    
calcium-dependent serine proteinase : golden hamster CASP_MESAU
tmc:P15156
    
cathepsin G: human CATG_HUMAN
xmc:1CGH
x:1cgh
x:1au8
a
a+ svpphep+sin,1.8A
a+svplph,1.9A
s, c, p, v, r, w
s, c, p, v, r, w
cathepsin G: mouse CATG_MOUSE
 
    
cathepsin G: rat CATG_RAT
 
    
cerastotin: horned desert viper CERA_CERCE
 
    
cerastobin: sahara sand viper CERA_CERVI
 
    
cercarial protease: blood fluke CERC_SCHMA
tmc:P12546
    
complement factor B: bovine CFAB_BOVIN
 
    
complement factor B: human CFAB_HUMAN
tmc:P00751
    
complement factor B: mouse CFAB_MOUSE
 
    
complement factor B : pig CFAB_PIG
 
    
complement factor D: human CFAD_HUMAN
xmc:1DSU
x:1dsu
x:1dst
tmc:P00746
a+b
a+b+dfp
mutant,2A

s, c, p, v, r, w
s, c, p, v, r, w
complement factor D: mouse CFAD_MOUSE
 
    
complement factor D : pig CFAD_PIG
 
    
complement factor D: rat CFAD_RAT
 
    
complement factor I: human CFAI_HUMAN
tmc:P05156
    
complement factor B-like protease: chicken CFBL_CHICK
 
    
caldecrin: rat CLCR_RAT
tmc:P55091
    
complement C2: human CO2_HUMAN
tmc:P06681
    
complement C2: mouse CO2_MOUSE
 
    
cocoonase: atlantic horseshoe crab COCO_LIMPO
 
    
collagenolytic protease 25 KD II/III: crab-beetle COG1_CHIOP
 
    
collagenolytic protease 28 KD : red king crab COG1_PARCM
 
    
collagenolytic protease 35 KD II: crab-beetle COG2_CHIOP
 
    
collagenolytic protease 36 KD: crab-beetle COG3_CHIOP
 
    
collagenolytic protease 36 KD A : red king crab COGA_PARCM
 
    
collagenolytic protease36 KD B : red king crab COGB_PARCM
 
    
collagenolytic protease36 KD C : red king crab COGC_PARCM
 
    
collagenase: cattle grub COGS_HYPLI
xmc:2HLC
x:2hlc
x:1hyl

a+b
a+b,1.7
a+b,1.8


s, c, p, v, r, w
s, c, p, v, r, w
collagenolytic protease (brachyurin): atlantic sand fiddler crab COGS_UCAPU
xmc:1AAZ
x:1azz
a+b
a+b+ecotin, 2.3A
s, c, p, v, r, w
complement -activating component of RA-reactive factor : human CRAR_HUMAN
 
    
complement -activating component of RA-reactive factor : mouse CRAR_MOUSE
 
    
chymotrypsin1: african malaria mosquito CTR1_ANOGA
tmc:Q27289
    
chymotrypsin BI: penoied shrimp, european white shrimp CTR1_PENVA
tmc:Q00871
    
chymotrypsin2: african malaria mosquito CTR2_ANOGA
 
    
chymotrypsin2: dog CTR2_CANFA
 
    
chymotrypsinBII: penoied shrimp, european white shrimp CTR2_PENVA
 
    
chymotrypsinII: european hornet CTR2_VESCR
 
    
chymotrypsinII : oriental hornet CTR2_VESOR
 
    
chymotrypsinA: bovine CTRA_BOVIN
xmc:1CBW
x:1cbw
+
+bpti,2.6A
s, c, p, v, r, w
chymotrypsinA: atlantic cod CTRA_GADMO
 
    
chymotrypsinB: bovine CTRB_BOVIN
xmc:4CHA
x:1ab9
x:3gct
x:1gct
x:8gch
x:1afq
x:2cga
x:5cha
x:4cha
x:1ghb
x:2gct
x:1cho
x:1gcd
x:2gmt
x:1gha
x:1gmh
x:1gmc
x:1gmd
x:1acb
x:7gch
x:6cha
x:1ca0
x:6gch
x:2gch
x:4gch
x:3gch
x:2cha
x:1cbw
x:1pyt
x:1cgi
x:1cgj
x:5gch
x:1mtn
x:1vgc
x:2vgc
x:3vgc
x:4vgc
x:1chg
x:1hja
a+b
a+b+c+so4
a+so4
a+so4
+so4
a+b+c+dle+fba+so4
a+b
a+b
a+b
:e+hex+ipa
:a+so4
chain e
+dep+so4
+ hin
e+ipa+so4
+isp+so4;
a
a+hex
e

a+b+pba
a+b+c+ f+g+h
+apf

+dmc
+cin
+tos
a+b+c+f+g+h+so4
d+Ca+Zn
e
e

a+b+c+f+g+hso4+bpti
a+b+c+so4+v36
a+b+c+so4+v35
a+b+c+so4+srb
a+b+c+so4+srd

mutant a+b+c+toitd
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
chymotrypsinB : atlantic cod CTRB_GADMO
 
    
chymotrypsinB: human CTRB_HUMAN
tmc:P17538
    
chymotrypsinB: rat CTRB_RAT
 
    
chymotrypsin-like serine proteinase : california red abalone CTRL_HALRU
tmc:P35003
    
chymotrypsin-like protease CTRL-1: human CTRL_HUMAN
 
    
chymotrypsin: penoeid shrimp. CTRP_PENMO
 
    
duodenase I: bovine DDN1_BOVIN
 
    
mite allergen der. F 3: house-dust mite DEF3_DERFA
tmc:P49275
    
mite allergen der. F 6: house-dust mite DEF6_DERFA
tmc:P49276
    
mite allergen der. P 3: house-dust mite DER3_DERPT
 
    
mite allergen der. P 6 : house-dust mite DER6_DERPT
 
    
serine protease easter: fruit fly EAST_DROME
tmc:P13582
    
elastase 1: bovine EL1_BOVIN
 
    
elastase 1 : human EL1_HUMAN
xmc:1PPF
x:1ppf
x:1hne
x:1ppg
e
e+fuc+glc+man+nag
e+alm+msu
e+fuc+glc+hmb+man+nag+vaf

s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
elastase 1: pig EL1_PIG
xmc:3EST
x:1elg
x:4est
x:3est
x:1elc
x:1esa
x:1nes
x:1elf
x:1bma
x:8est
x:1ele
x:1ela
x:1eas
x:6est
x:9est
x:1eld
x:1lvy
x:1inc
x:1eau
x:5est
x:1elb
x:1eat
x:1fle
x:7est
x:1jim
x:1esb
x:2est
x:1est
+
1elg:+baa+Ca
e+Ca+fpa+so4
+Ca+so4
a+Ca+ iso+ tfa
e+Ca+so4
e+Ca+so4
+baf+ca+so4
a+Ca+iso+mbh+so4+ tfa
e+Ca+gis+so4
e+ani+Ca+so4+tfa
a+acy+Ca+iso+so4+tfa
+Na+so4+tfk
+Ca+dmf+so4
+Ca+ibr+so4
e+acy+ ani+Ca+tfa
+Ca+so4
+Ca+icl+so4
+bdk+Na+so4
e+b2i+Ca+cbz+so4
a+Ca+iso+iso4+tfa
e+Na+so4+tfi
e
e+ani+Ca+dmf+so4+tfa
+icu+so4
+Ca+cbz+so4
e+ani+so4+tfa
+so4+tos


s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w

elastase 1: rat EL1_RAT
 
    
neutrophil elastase 2A : horse EL2A_HORSE
 
    
elastase 2A: human EL2A_HUMAN
tmc:P08217
    
neutrophil elastase 2B : horse EL2B_HORSE
 
    
elastase 2B: human EL2B_HUMAN
tmc:P08218
    
elastase 2: bovine EL2_BOVIN
 
    
elastase 2: mouse EL2_MOUSE
 
    
elastase 2: pig EL2_PIG
 
    
elastase 2: rat EL2_RAT
 
    
elastase IIIA: human EL3A_HUMAN
 
    
elastase IIIB: human EL3B_HUMAN
 
    
elastase : salmon  
xmc:1ELT
x:1elt

+Ca

s, c, p, v, r, w
elastase : atlantic cod ELAS_GADMO
 
    
leukocyte elastase: human ELNE_HUMAN
 
    
enteropeptidase: bovine ENTK_BOVIN
 
    
enteropeptidase: human ENTK_HUMAN
tmc:P98073
    
enteropeptidase: mouse ENTK_MOUSE
 
    
enteropeptidase: pig ENTK_PIG
 
    
arginine esterase: dog ESTA_CANFA
tmc:P09582
    
coagulation factor X: bovine FA10_BOVIN
 
    
coagulation factor X: chicken FA10_CHICK
 
    
coagulation factor X: human


          chymera fX & trypsin + PPACK
 FA10_HUMAN
xmc:1HCG
x:1hcg,2.2A
x:1fax
x:1fxy,2.15A
a
a
a mutant+Ca+dx9
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
coagulation factor X: rabbit FA10_RABIT
 
    
coagulation factor XI: human FA11_HUMAN
tmc:P03951
    
coagulation factor XII: bovine FA12_BOVIN
 
    
coagulation factor XII: guinea pig FA12_CAVPO
 
    
coagulation factor XII: human FA12_HUMAN
tmc:P00748
    
coagulation factor VII: bovine FA7_BOVIN
 
    
coagulation factor VII: human FA7_HUMAN
xmc:1DAN
x:1dan
 h
h+Ca+cac+cgu+ch2+dpn+fuc+ glc+tf
s, c, p, v, r, w
coagulation factor VII: mouse FA7_MOUSE
 
    
coagulation factor VII: rabbit FA7_RABIT
 
    
coagulation factor IX: bovine FA9_BOVIN
 
    
coagulation factor IX: dog FA9_CANFA
 
    
coagulation factor IX : guinea pig FA9_CAVPO
 
    
coagulation factor IX: human FA9_HUMAN
tmc:P00740
    
coagulation factor IX: mouse FA9_MOUSE
 
    
coagulation factor IX : pig FA9_PIG
xmc:1PFX
x:1pfx,3A
c
c+cgu+doh+ppack
s, c, p, v, r, w
coagulation factor IX : rabbit FA9_RABIT
 
    
coagulation factor IX : rat FA9_RAT
 
    
coagulation factor IX : sheep FA9_SHEEP
 
    
flavoxobin: habu FLVB_TRIFL
 
    
gilatoxin: beaded lizard GILX_HELHO
 
    
granzyme A: human GRAA_HUMAN
 
    
granzyme A: mouse GRAA_MOUSE
 
    
granzyme B: human GRAB_HUMAN
tmc:P10144
    
granzyme B (G,H): mouse GRAB_MOUSE

tmc:2CP1
t:2cp1

   
granzyme C: mouse GRAC_MOUSE
 
    
granzyme D: mouse GRAD_MOUSE
tmc:P11033
    
granzyme E: mouse GRAE_MOUSE
 
    
granzyme F: mouse GRAF_MOUSE
tmc:P08883
    
granzyme G: mouse GRAG_MOUSE
 
    
granzyme H: human GRAH_HUMAN
 
    
granzyme K: human GRAK_HUMAN
 
    
granzyme K: mouse GRAK_MOUSE
 
    
granzyme K: rat GRAK_RAT
 
    
granzyme M: human GRAM_HUMAN
 
    
granzyme M: rat GRAM_RAT
 
    
granzyme-like protein I: rat GRL1_RAT
 
    
granzyme-like protein II: rat GRL2_RAT
tmc:Q06606
    
halistase: gloydius blomhoffii HAYS_AGKHA
 
    
serine protease hepsin : human HEPS_HUMAN
tmc:P05981
    
serine protease hepsin : mouse HEPS_MOUSE
 
    
serine protease hepsin : rat HEPS_RAT
 
    
hepatocyte growth factor activator: human HGFA_HUMAN
tmc:P04756
    
hepatocyte growth factor -like protein: human HGFL_HUMAN
tmc:P26297
    
hepatocyte growth factor -like protein: mouse HGFL_MOUSE
 
    
hepatocyte growth factor (scatter factor ) : human HGF_HUMAN
tmc:P14210
    
hepatocyte growth factor (scatter factor ) : mouse HGF_MOUSE
 
    
hepatocyte growth factor (scatter factor ) : rat HGF_RAT
 
    
hypodermin A: cattle grub HYPA_HYPLI
tmc:P35587
    
hypodermin B: cattle grub HYPB_HYPLI
tmc:P35588
    
plasma kallikrein: human KAL_HUMAN
tmc:P03952
    
plasma kallikrein: mouse KAL_MOUSE
 
    
plasma kallikrein: rat KAL_RAT
 
    
plasma kallikrein: pig  
xmc:2PKA
x:2pka
x:1hia
x:2kai
a+b
a+b+ben+ x+y
a+b+ x+y
a+b
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
glandular kallikrein, submandibular : guinea pig KLK1_CAVPO
 
    
glandular kallikrein1: human KLK1_HUMAN
tmc:P06870
    
glandular kallikrein1: crabeating macaque, cynomolgus monkey KLK1_MACFA
 
    
glandular kallikrein K1: mouse KLK1_MOUSE
 
    
glandular kallikrein1hamadryas babboon KLK1_PAPHA
 
    
glandular kallikrein, pancreatic 1: rat KLK1_RAT
 
    
glandular kallikrein, prostatic : guinea pig KLK2_CAVPO
 
    
glandular kallikrein 2: human KLK2_HUMAN
 
    
tonin: rat KLK2_RAT
xmc:1TON
1ton

+Zn
s, c, p, v, r, w
glandular kallikrein K3: mouse KLK3_MOUSE
 
    
glandular kallikrein 3, submandibular : rat KLK3_RAT
 
    
7S nerve growth factor alpha chain: mouse KLK4_MOUSE
xmc:1SGF
x:1sgf,3.15A

a+g+x+z+nag+Zn
s, c, p, v, r, w
glandular kallikrein K5: mouse KLK5_MOUSE
 
    
glandular kallikrein K6: mouse KLK6_MOUSE
 
    
glandular kallikrein 7, submandibular/renal: rat KLK7_RAT
 
    
glandular kallikrein K8: mouse KLK8_MOUSE
 
    
glandular kallikrein 8, prostatic: rat KLK8_RAT
 
    
glandular kallikrein K9: mouse KLK9_MOUSE
 
    
glandular kallikrein 9, submandibular: rat KLK9_RAT
 
    
glandular kallikrein K11: mouse KLKA_MOUSE
 
    
glandular kallikrein 10: rat KLKA_RAT
 
    
glandular kallikrein 12, submandibular/renal: rat KLKB_RAT
 
    
glandular kallikrein K13: mouse KLKC_MOUSE
xmc:1AO5
x:1ao5,2.6A
a+b
a+b+nag
s, c, p, v, r, w
gamma-renin, submandibular gland: mouse KLKF_MOUSE
tmc:P04071
    
glandular kallikrein K22: mouse KLKL_MOUSE
 
    
glandular kallikrein, renal: african soft furred rat KLKR_PRANA
 
    
glandular kallikrein K26: mouse KLKZ_MOUSE
 
    
glandular kallikrein: pig KLK_PIG
 
    
chymotrypsin-like serine proteinase : human LCLP_HUMAN
tmc:P34168
    
limulus clotting factor C: japanese horseshoe crab LFC_TACTR
tmc:P28175
    
chymase: dog MCT1_CANFA
 
    
chymase: human MCT1_HUMAN
tmc:P23946
    
chymase: crabeating macaque, cynomolgus monkey MCT1_MACFA
 
    
mast cell protease 1: mongolian jird MCT1_MERUN
 
    
mast cell protease 1: mouse MCT1_MOUSE
tmc:P11034
    
chymasehamadryas babboon MCT1_PAPHA
 
    
mast cell protease I: rat MCT1_RAT
 
    
mast cell protease1A: sheep MCT1_SHEEP
 
    
mast cell protease 2: mongolian jird MCT2_MERUN
 
    
mast cell protease 2: mouse MCT2_MOUSE
tmc:P15119
    
mast cell protease II (chymase2): rat MCT2_RAT
xmc:3RP2
x:3rp2,1.9A
a+b
a+b
s, c, p, v, r, w
mast cell protease3 : mouse MCT3_MOUSE
 
    
mast cell protease III: rat MCT3_RAT
 
    
mast cell protease 4: mouse MCT4_MOUSE
 
    
mast cell protease 5: mouse MCT5_MOUSE
 
    
mast cell protease 6: mouse MCT6_MOUSE
 
    
mast cell protease 7: mouse MCT7_MOUSE
 
    
mast cell protease 7: rat MCT7_RAT
 
    
mast cell protease 8: mouse MCT8_MOUSE
tmc:P43430
    
mast cell protease 9: mouse MCT9_MOUSE
 
    
mast cell protease-like protein: mouse MCTX_MOUSE
tmc:Q00356
    
serine protease nudel: fruit fly NDL_DROME
tmc:P98159
    
natural killer cell protease1: rat NKP1_RAT
tmc:P18291
    
neutrophil proteinase 4 : human NP4_HUMAN
 
    
okimaxobin I : hime-habu OKI1_TRIOK
 
    
proclotting enzyme: japanese horseshoe crab PCE_TACTR
tmc:P21902
    
plasmin: bovine PLMN_BOVIN
 
    
plasmin : dog PLMN_CANFA
 
    
plasmin: western european hedgehog PLMN_ERIEU
 
    
plasmin: horse PLMN_HORSE
 
    
plasmin: human PLMN_HUMAN
tmc:P00747
    
plasmin: rhesus macaque PLMN_MACMU
 
    
plasmin: mouse PLMN_MOUSE
 
    
plasmin: sea lamprey PLMN_PETMA
 
    
plasmin : pig PLMN_PIG
 
    
plasmin: rat PLMN_RAT
 
    
plasmin: sheep PLMN_SHEEP
 
    
myeloblastin: human PRN3_HUMAN
xmc:1FUJ
x:1fuj

a+b+c+d+fuc+nag
s, c, p, v, r, w
prostate specific antigen: human PROS_HUMAN
tmc:P07288
    
prostate specific antigen: rhesus macaque PROS_MACMU
 
    
protease A: streptomyces griseus  
xmc:2SGA
x:2sga
x:3sga
x:1sgc
x:4sga
x:5sga


e+pha
+cst
e
e 		 
protease B: streptomyces griseus  
xmc:3SGB
x:3sgb
x:4sgb
x:1sgp
x:1sgr
x:1sgq
e
e
e+Ca+so4
e mutant+ po4
e mutant+ po4
e mutant+ po4
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
vitamin-K dependent protein C: bovine PRTC_BOVIN
 
    
vitamin-K dependent protein C : dog PRTC_CANFA
 
    
vitamin-K dependent protein C : goat PRTC_CAPHI
 
    
vitamin-K dependent protein C : cat PRTC_FELCA
 
    
vitamin-K dependent protein C : horse PRTC_HORSE
 
    
vitamin-K dependent protein C: human PRTC_HUMAN
xmc:1AUT
x:x:1aut,2.8A
x:t:1pcu
x:t:2pct
 c
c+ bhd+dpn+mai, 2.8A
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
vitamin-K dependent protein C: rhesus macaque PRTC_MACMU
 
    
vitamin-K dependent protein C: mouse PRTC_MOUSE
 
    
vitamin-K dependent protein C: rabbit PRTC_RABIT
 
    
vitamin-K dependent protein C: rat PRTC_RAT
 
    
protease serine-like 1: human PSL1_HUMAN
 
    
prostasin: human PSS8_HUMAN
tmc:Q16651
    
protease M: human PSS9_HUMAN
 
    
proteinase RVV-V alpha: russell viper RVVA_DABRU
 
    
proteinase RVV-V gamma: russell viper RVVG_DABRU
 
    
serine proteaseSP24D: african malaria mosquito S24D_ANOGA
tmc:Q17004
    
stratum corneum chymotryptic enzyme: human SCCE_HUMAN
tmc:P49862
    
serine protease S 1 and 2: fruit fly SER1_DROME
tmc:P17205
    
serine protease3 : fruit fly SER3_DROME
 
    
serine protease snake: fruit fly SNAK_DROME
tmc:P05049
    
serine proteinase stubble : fruit fly STUB_DROME
tmc:Q05319
    
thrombin: bovine
          epsilon + MQPA

          epsilon + NAPAP

          epsilon + 4- TAPAP


          alpha + rhodniin inhibitor

          alpha + fibrinopeptide alpha

          alpha + rhodniin inhibitor
          alpha + hirudin variant 1

          alpha- thrombin; complex with hirugen






          alpha + hirugen + cyclotheonamide A
          alpha + hirugen + dansylArg-N-(3-ethyl-1,5- pentanediyl)amide
          prothrombin fragment 1
          prothrombin fragment 1 + Ca
          prothrombin fragment 1 + Sr		 THRB_BOVIN

xmc:1HRT
x:1etr,2.2A
x:1ucy
x:1ets,2.3A
x:1dit
x:1ett,2.5A
x:1mkx
x:1bmn
x:1tbr,2.6A
x:1mkw
x:1bbr,2.3A
x:1bmm
x:1tbq,3.1A
x:1hrt,2.8A
x:1toc
x:1hdt,2.6A
x:1uvs
x:1uvt
x:1uvu
x:1bth
x:1ycp
x:1a0h
x:1tmb,2.3A
x:1fpc,2.3A
x:2pf1,2.2A
x:2pf2,2.2A
x:2spt,2.5A


l,h+mcp+mqpa
l,h,e+j,k+m,n+ace+opr
l,h+nas+pap+pip
l,h+2pp+cbx
l,h+pap+pip+tos
l,h+k
l,h+bm9
l,h+j,k
l,h+k
l,h+e+j,k+m,n
l,h+bm2
l,h+j,k
l,h
a,b+c,d+e,f+g,h
l,h+alg+alo+ch3+so3
l,h+bm12+ i11
l,h+bm12+ i48
l,h+bm12+dch
l,h mutant+j,k
l,h+j,k,m
a,b,e+ch2+dpn+nag
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
 s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
thrombin: human
 
          alpha + hirutonin- 2
          alpha + peptidyl pyridinium methyl ketone
          alpha + PPACK
          alpha + hirutonin- 6

          alpha + CGP 50,856





          alpha + MDL- 28050
          alpha + hirugen + dansylArg-N-ethyl-pentanediyl-amide
          alpha +hirudin + fibrinopeptide A
          alpha + PPACK

          alpha + hirugen

          alpha + hirugen + fibrinopeptide A mimic
          alpha + hirulog 3
          alpha + hirugen + cyclotheonamide A
          alpha+ hirudin fragment + PPACK

          alpha + hirugen
          alpha + hirulog 1
          alpha + des- Asp55 hirudin + MD- 805
          alpha + hirullin
          prethrombin + hirugen
          alpha + PPACK
          alpha + des- Asp55 hirudin + PPACK
          alpha + receptor based peptide NRP + hirugen
          alpha + r-hirudin variant 2
          alpha + des- Asp55 hirudin + benzamidine
          alpha + des- Asp55 hirudin + NAPAP
          gamma
          alpha + PPACK + thrombomodulin

          alpha + receptor based peptide D- FPR'S
          alpha + r-hirudin variant 2
          alpha + receptor based peptide NR'S
          alpha + receptor based peptide NRP
          alpha + receptor based peptide XA + PPACK
          alpha + PPACK and bovine prothrombin fragment 2
          alpha + PPACK and bovine prothrombin fragment 2
          alpha + DNA + PPACK
          alpha + 15- mer oligonucleotide
          alpha + 15- mer oligonucleotide
          alpha + p- amidino- Phe- pyruvate
          alpha + hirugen + active site inhibitor
          alpha + hirugen + active site inhibitor
          alpha + hirudin variant I
          alpha + hirudin I + EOC- D- Phe- Pro- azaLys- ONP inhibitor
          alpha + hirudin I + CBZ-Pro-azaLys-ONP inhibitor


          alpha + hirudin I + thiazole- containing inhibitor
          alpha + hirugen + beta- strand mimetic inhibitor
          alpha + hirugen + active site inhibitor

          alpha + boronate form of hirudin II inhibitor
          alpha + boronate form of hirudin II inhibitor
          alpha + hirudin IIIB' inhibitor

          alpha + aeruginosin inhibitor
          alpha + hirugen
          alpha + hirugen + fibrinopeptide A mimic
          alpha + bpti
          alpha + SDZ 229- 357 inhibitor
          meizothrombin 		THRB_HUMAN
xmc:1PPB
x:1tom
x:1ihs,2A
x:1hbt,2A
x:1ppb,1.92A
x:1iht,2.1A
x:1lhc
x:1tmt,2.2A
x:1hxe
x:1uma
x:1hxf
x:1lhe
x:1lhg
x:1ths,2.2A
x:1fpc,2.3A
x:1fph,2.5A
x:1hai,2.4A
x:1nrr
x:1hah,2.3A
x:1lhd
x:3hat,2.5A
x:1abi,2.3A
x:1tmb,2.3A
x:1tmu,2.5A
x:1lhf
x:1hgt,2.2A
x:2hgt,2.2A
x:1dwc,3A
x:1thr,2.3A
x:1hag,2.3A
x:1abj,2.4A
x:1dwe,3A
x:1nrs,2.4A
x:4htc,2.3A
x:1dwd,3A
x:1dwb,3.16A
x:2hnt,2.5A
x:1hlt,3A
x:1vit
x:1nrq,3.5A
x:3htc,2.3A
x:1nrp,3A
x:1nro,3.1A
x:1nrn,2.4A
x:2hpp,3.3A
x:2hpq,3.3A
x:1hut,2.9A
x:1hao,2.8A
x:1hap,2.8A
x:1aht,1.6A
x:1ai8,1.85A
x:1aix,2.1A
x:1ad8,2A
x:1ae8,2A
x:1afe,2A
x:5gds
x:1ay6
x:1a4w,1.8
x:1a46,2.12A
x:1a5g,2.1A
x:1b5g
x:1a3b,1.8A
x:1a3e,1.85A
x:1a61,2.2A
x:1tbz
x:1a2c,2.1A
x:1hdt,2.6A
x:2hat,2.5A
x:1bth,2.3A
x:1bhx,2.3A
x:1a0h,3.2A
l+h
l,h+min+tys
l,h+pnl
l,h+chx+paa
l,h+ppack
l,h+fbe+ptl
l,h+dp7
l,h+nag
l,h+Rb
:l,h+in2+ nag+sfo
l,h
l,h+ppbbag(di3)
l,h+ppbo(di5)
l,h+chx+sin
l,h+ans+epi+so3
l,h+ppack
l,h+ppack+nag
l,h+ppack
l,h+nag+sfo
l,h+ppb(di2)
l,h+rng+so3
l,h+hmr
l,h+aht+sfn
l,h+ppack+nag+so3
l,h+ppb(di4)
l,h+sfn
l,h
l,h+md805
l,h
e+nag+sfo
l,h+ppack
l,h+ppack
l,h+sfn
l,h+nag
l,h+napap+mid
l,h+ben
l,c,e,f
l,h+ppack+ j,k
l,h+nag+m,f,g
l,h+hmr; chain l,h
l,h
l,h+hmr
l,h
l,h
l,h+ppack
l,h+ppack
l,h+ppack
l,h+ppack
l,h+ppack
l,h+apa+sfo
l,h+t42+tys
l,h+t19tys
l,h+mdl103752+Na+tys
l,h+azl+ nag+ tys
l,h+alz+ nag+ tys
l,h+aib+chg+dgl+hac+nag+nal
l,h+hho+hmf+tys
l,h+ans+kth+Na+tys
l,h+bcy+Na+oho+rng+tys
l,h+bic+eoa+Na+tys
l,h+bcc+Na+thz+tys
l,h+t29
l,h+t16
l,h+lom+ mol+Na+tys
l,h+bot+dpn+Na+tys
l,h+Na+oar+oph+rph+tys
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w

thrombin: mouse

 THRB_MOUSE
 
    
thrombin: rat THRB_RAT
 
    
gyroxin analog: bushmaster THRL_LACMU
 
    
transmembrane protease, serine2 : human TMS2_HUMAN
 
    
trypsin1: african malaria mosquito
 TRY1_ANOGA
 
    
trypsin,cationic: bovine TRY1_BOVIN
xmc:1TLD
x:5ptp
x:1bty
x:1tpp
x:1tld
x:3ptb
x:2ptn
x:1tnh
x:1btw
x:1tnk
x:1jrs
x:1jrt
x:2tgt
x:1ppc
x:1btx
x:1btz
x:1tgs
x:1tpo
x:1pph
x:1tps
x:1tgt
x:1mts
x:3ptn
x:1tnj
x:1tgc
x:1tng
x:1tyn
x:1may
x:1ntp
x:1tni
x:1taw
x:2tga
x:1tnl
x:1tgn
x:1tpa
x:1ppe
x:1gbt
x:2ptc
x:1max
x:2tgp
x:3tp
x:1smf
x:4tpi
x:2tpi
x:1btp
x:1tgb
x:2tgd
x:1tab
x:1aq7
x:2tld

+Ca+mis
+ben+Ca
+apa+Ca+so4
+Ca+so4
+ben+Ca
+Ca
+Ca+fba
a+Ca+bly+boc+hpg
+Ca+ pra
a+Ca+ace
a+Ca+ace
+Ca+moh
e+Ca+aph+nas+pip
a+Ca+bly+boc+ety
a+Ca+bly+boc+ch3
z+Ca+so4
+Ca
e+Ca+apm+pip+so4+tos
+Ca+a90720a
+Ca+moh
+Ca+bx3
+Ca
+Ca+ pea
+Ca
+Ca+amc
+cta
+Ca+zap
+Ca+ser195mip
+Ca+pbn
a+Ca
+Ca
+Ca+tpa

e+Ca
e
+Ca+ser195gbs+so4
e+Ca
+Ca+zap
z+Ca+so4
z+Ca+so4
e+Ca
z+Ca+so4
z+Hg
+Ca
+Ca
+Ca+ser195dip
e
+aeb
e
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
trypsin,cationic: dog TRY1_CANFA
 
    
trypsin I-P1 : chicken TRY1_CHICK
 
    
trypsin I: atlantic cod TRY1_GADMO
xmc:2TBS
x:1bit
x:2tbs
+ben+Ca+so4
+ben+Ca
s, c, p, v, r, w
s, c, p, v, r, w
trypsin I: human TRY1_HUMAN
xmc:1TRN
x:1trn
x:1fxy
 a+b
a+b+isp+po4
chymera fX,trypsin
s, c, p, v, r, w
s, c, p, v, r, w
trypsin I, anionic: rat
 TRY1_RAT

xmc:1BRC
x:1brb
x:1ane
x:1bra
x:1brc
x:1mtu
x:1mtv
x:1mtw
x:1amh
x:1tfx
x:1an1
x:1dpo
x:1slu
x:1slx
x:1slw
x:1slv
x:1and
x:1anc
x:1trm
x:1anb
x:2trm
e mutant+bpti mutant
ben
+Ca+ben
e
+Ca+bx3
+Ca+bx3
+Ca+dx9
a,b mutant+Ca
a,b+Ca+Xinhib c,d
e mutant+Ca+das
mutant+Ca+bdn+so4
b mutant+Ca+act
b mutant+Ca+act+Zn
b mutant+Ca+act+Ni
b mutant+Ca+act+Cu
mutant+ben+Cu
mutant+Ca+ben
a,b mutant+ben+ca
mutant+Ca+ ben
mutant+Ca+ben
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
trypsin I: atlantic salmon TRY1_SALSA
 
    
trypsin: yellowfever mosquito TRY1_XENLA
 
    
trypsin 2: african malaria mosquito TRY2_ANOGA
 
    
trypsin, anionic: bovine TRY2_BOVIN
 
    
trypsin, anionic: dog TRY2_CANFA
 
    
trypsin I-P38 : chicken TRY2_CHICK
 
    
trypsin II: human TRY2_HUMAN
tmc:P07478
    
trypsin II, anionic: rat TRY2_RAT
 
    
trypsin II: atlantic salmon TRY2_SALSA
 
    
trypsin: yellowfever mosquito TRY2_XENLA
 
    
trypsin 3A1: yellowfever mosquito TRY3_AEDAE
 
    
trypsin3: african malaria mosquito TRY3_ANOGA
 
    
trypsin II-P29 : chicken TRY3_CHICK
 
    
trypsin III: human TRY3_HUMAN
 
    
trypsin alpha-3: green-bottle fly, australian sheep blowfly TRY3_LUCCU
 
    
trypsin III, cationic: rat TRY3_RAT
 
    
trypsin III: atlantic salmon TRY3_SALSA
 
    
trypsin 4: african malaria mosquito TRY4_ANOGA
 
    
trypsin 4A: human TRY4_HUMAN
 
    
trypsin alpha-4: green-bottle fly, australian sheep blowfly TRY4_LUCCU
 
    
trypsin IV: rat TRY4_RAT
 
    
trypsin 5G1: yellowfever mosquito TRY5_AEDAE
 
    
trypsin 5: african malaria mosquito TRY5_ANOGA
 
    
trypsin 6: african malaria mosquito TRY6_ANOGA
 
    
trypsin 7: african malaria mosquito TRY7_ANOGA
 
    
trypsin alpha:fruit fly TRYA_DROER
 
    
trypsin alpha: fruit fly TRYA_DROME
tmc:P04814
    
alpha-tryptase: human TRYA_HUMAN
tmc:P15157
    
trypsin, alkaline A : tobacco hawkmoth, horworm TRYA_MANSE
 
    
trypsin V-A: rat TRYA_RAT
 
    
trypsin beta:fruit fly TRYB_DROER
 
    
trypsin beta: fruit fly TRYB_DROME
 
    
beta-tryptase: human TRYB_HUMAN
 
    
trypsin, alkaline B : tobacco hawkmoth, horworm TRYB_MANSE
 
    
trypsinV-B: rat TRYB_RAT
 
    
trypsin, alkaline C : tobacco hawkmoth, horworm TRYC_MANSE
 
    
trypsin delta/gamma: fruit fly TRYD_DROER
 
    
trypsin delta: fruit fly TRYD_DROME
 
    
trypsin epsilon: fruit fly TRYE_DROER
 
    
trypsin epsilon: fruit fly TRYE_DROME
 
    
trypsin gamma: fruit fly TRYG_DROME
 
    
trypsin iota: fruit fly TRYI_DROME
 
    
tryptase-like protease: rat TRYL_RAT
 
    
mastocytoma protease: dog TRYM_CANFA
 
    
mast cell tryptase: rat TRYM_RAT
 
    
trypsin I , : broad-fingered crayfish TRYP_ASTFL
 
    
trypsin CFT-1: spruce budworm TRYP_CHOFU
 
    
trypsin: cat TRYP_FELCA
 
    
trypsin: fusarium oxysporum TRYP_FUSOX
xmc:1TRY
x:1try
+ipa+isp;
s, c, p, v, r, w
trypsin: mouse TRYP_MOUSE
 
    
trypsin: penoeid shrimp. TRYP_PENMO
 
    
trypsin: pig TRYP_PIG
xmc:1MCT
x:1mct
x:1ept
x:1aks
x:1ldt
 a+Ca
a+Ca
a+b+c+Ca
a+b+Ca
t+Ca
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
s, c, p, v, r, w
trypsin: plaise TRYP_PLEPL
 
    
trypsin: marbled lungfish TRYP_PROAT
 
    
trypsin: streptomyces erythraeus TRYP_SACER
 
    
trypsin: grey flesh fly TRYP_SARBU
 
    
trypsin: black fly TRYP_SIMVI
 
    
trypsin: spiny dogfish TRYP_SQUAC
 
    
trypsin-like protease: streptomyces glaucescens TRYP_STRGA
 
    
trypsin: streptomyces griseus TRYP_STRGR
xmc:1SGT
x:1sgt

+Ca
s, c, p, v, r, w
tryptase: dog TRYT_CANFA
 
    
trypsin theta: fruit fly TRYT_DROER
 
    
trypsin theta: fruit fly TRYT_DROME
 
    
mast cell tryptase: mongolian jird TRYT_MERUN
 
    
trypsineta: fruit fly TRYU_DROER
 
    
trypsineta: fruit fly TRYU_DROME
 
    
trypsinX: atlantic cod TRYX_GADMO
 
    
trypsin zeta: fruit fly TRYZ_DROER
 
    
trypsin zeta: fruit fly TRYZ_DROME
 
    
urokinase-type plasmin activator: bovine UROK_BOVIN
 
    
urokinase-type plasmin activator: chicken UROK_CHICK
 
    
urokinase-type plasmin activator: human UROK_HUMAN
xmc:1LMW
x:1lmw
 a+b
a+b+c+d+arm
s, c, p, v, r, w
urokinase-type plasmin activator: mouse UROK_MOUSE
 
    
urokinase-type plasmin activator: yellow baboon UROK_PAPCY
 
    
urokinase-type plasmin activator: pig UROK_PIG
 
    
urokinase-type plasmin activator: rat UROK_RAT
 
    
tissue plasmin activator: bovine UROT_BOVIN
 
    
tissue plasmin activator: human UROT_HUMAN
xmc:1RTF
x:1rtf
 a+b
a+b+ben+po4
s, c, p, v, r, w
tissue plasmin activator: mouse UROT_MOUSE
 
    
tissue plasmin activator: rat UROT_RAT
 
    
salivary plasmin activator alpha 1: vampire bat URT1_DESRO
tmc:P98119
    
salivary plasmin activator alpha 2: vampire bat URT2_DESRO
 
    
salivary plasmin activator beta: vampire bat URTB_DESRO
 
    
salivary plasmin activator gamma: vampire bat URTG_DESRO
 
    
vitellin-degradingprotease: silk moth VDP_BOMMO
tmc:Q07943
    
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Thierry Rose, PhD and Enrico Di Cera, MD
Department of Biochemistry and Molecular Biophysics
Washington University School of Medicine
Saint Louis, MO, U.S.A.
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