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We are still working on this beta version. Tools, links and database extension will be added and opened gradually until the end of August, the date of the first release. You can find more about the schedule in "what's next ?" |
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To find sequences, click the link to the corresponding clan or family in the table below or click all serine proteases to access the entire list of serine proteases (500Kb-document). If you look for sequences to make sets go to sequence analyzer (make sets). You can browse your sequence from search. All these facilities allow you to get direct links to the sequence through the corresponding database |
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Overview of the Classification
of Serine Proteases See legends |
| Clan |
Family |
Seq
|
Pro
|
Enz
|
Str
|
3D
|
H-S-D-F-O-C |
Representative enzyme |
| SA | S1 |
339
|
|
40
|
|
37
|
H S D F O C | Chymotrypsin |
| S2 |
24
|
|
5
|
|
6
|
Alpha-Lytic endopeptidase | ||
| S2 A |
11
|
|
4
|
|
5
|
H S D F O C | Alpha-Lytic endopeptidase | |
| S2 B |
5
|
|
1
|
|
1
|
H S D F O C | Glutamyl endopeptidase (V8) | |
| S2 C |
8
|
|
0
|
|
0
|
H S D F O C | Protease Do (htrA) (Escherichia) | |
| S3 |
15
|
|
1
|
|
1
|
H S D F O C | Togavirin | |
| S4 |
|
|
|
|
|
S4 included in S2 | ||
| S5 |
1
|
|
1
|
|
0
|
H S D F O C | Lysyl endopeptidase | |
| S6 |
8
|
|
1
|
|
0
|
H S D F O C | IgA-specific serine endopeptidase | |
| S7 |
1
|
|
1
|
|
0
|
H S D F O C | Flavivirin | |
| S29 |
1
|
|
1
|
|
1
|
H S D F O C | Hepatitis C virus NS3 endopeptidase | |
| S30 |
1
|
|
0
|
|
0
|
H S D F O C | Tobacco etch virus 35 Kd endopeptidase | |
| S31 |
4
|
|
0
|
|
0
|
H S D F O C | Cattle diarrhea virus p80 endopeptidase | |
| S32 |
2
|
|
0
|
|
0
|
H S D F O C | Equine arteritis virus putative endopeptidase | |
| S35 |
3
|
|
0
|
|
0
|
H S D F O C | Apple stem grooving virus serine endopep. | |
| SB | S8 |
95
|
|
13
|
|
12
|
H S D F O C | Subtilases |
| S8A |
?
|
|
8
|
|
12
|
H S D F O C | Subtilisin | |
| S8B |
?
|
|
4
|
|
0
|
H S D F O C | Kexin | |
| S8C |
? |
|
1
|
|
0
|
H S D F O C | Tripeptidyl-peptidase II | |
| SC | S9 |
26
|
|
|
|
|
H S D F O C | Prolyl oligopeptidase |
| S9A |
10
|
|
2
|
|
0
|
H S D F O C | Prolyl oligopeptidase | |
| S9B |
10
|
|
1
|
|
0
|
H S D F O C | Dipeptidyl-peptidase IV | |
| S9C |
6
|
|
1
|
|
0
|
H S D F O C | Acylaminoacyl-peptidase | |
| S10 |
33
|
|
5
|
|
4
|
H S D F O C | Carboxypeptidase C | |
| S15 |
3
|
|
1
|
|
0
|
H S D F O C | Lactococcus X-Pro dipeptidyl-peptidase | |
| S28 |
1
|
|
2
|
|
0
|
H S D F O C | Lysosomal Pro-X carboxypeptidase | |
| SE | S11 |
13
|
|
1
|
|
1
|
H S D F O C | D-Ala-D-Ala peptidase family 1 |
| S12 |
2
|
|
2
|
|
3
|
H S D F O C | D-Ala-D-Ala peptidase family 2 | |
| S13 |
4
|
|
1
|
|
0
|
H S D F O C | D-Ala-D-Ala peptidase family 3 | |
| SG | S14 |
30
|
|
1
|
|
1
|
H S D F O C | ClpP endopeptidase |
| S16 |
30
|
|
1
|
|
0
|
H S D F O C | Endopeptidase La (Lon) | |
| S20 |
|
|
|
|
|
S20 included in S2 | ||
| SF | S24 |
15
|
|
1
|
|
1
|
H S D F O C | LexA repressor |
| S25 |
|
|
|
|
|
S25 is moved to threonine protease class | ||
| S26 |
20
|
|
1
|
|
1
|
H S D F O C | Bacterial leader peptidase I | |
| S27 |
5
|
|
|
|
|
H S D F O C | Eukaryote signal peptidase | |
| - | S18 |
4
|
|
1
|
|
0
|
H S D F O C | Omptin |
| - | S19 |
1
|
|
0
|
|
0
|
H S D F O C | Coccidiodes endopeptidase |
| - | S21 |
16
|
|
1
|
|
3
|
H S D F O C | Assemblin (Herpesviruses protease) |
| |
Legends: |
| Clan & family = link to the corresponding sequences Sequence = number of sequences - link to the most representative. Proteases = number of different proteases, i.e. trypsins of different species are counted as 1. Enzyme = number of enzymes with distinct E.C. entries. Structures = total number of structures including a serine protease domain - link to the most representative. 3D = number of structures including distinct serine protease domains HSSP - sequence alignment of the family from structural superpositions ProSite - Patterns of the current family ProDom - Homologous domains of the family SCOP - structural classification of proteins - fold of the family CATH - Structure classification of the family Representative enzyme = link to corresponding sequence of family representative protease. |
   |
Thierry Rose, PhD and Enrico
Di Cera, MD |
This web page has been updated the
© Copyright 1999 2000 - Netellise - All rights reserved.