Click the orange button in the menu above or the orange bullet in the descriptive menu below. A Red bullet means the corresponding page is not yet released. If you click on it you will find an estimate of the release date and its current state of development.

How do you setup your browser to optimize the display of our pages?
We make our best to allow most of the recent browsers to display and activate our pages.
Browsers:

Explorer 3.0 and after.
Mosaic 2.0 and after.
Netscape 3.0 and after.
Best with Explorer 5.0 and Netscape 4.6

• PC

Windows 95/98/NT:
select settings/control panel/display/settings
fix the cursor at the wanted resolution in the controle area scale
apply and confirm if the display looks good.

• Mac

system 7.0 and after:
select apple menu/control panel/display/settings
fix the cursor at the wanted resolution in the controle area scale
apply and confirm if the display looks good.

How do you setup your browser to use Chime?

MDL develops and supports Chime. See some examples and tutorials from the list of bio-molecular applications sorted by subject.
Chime 2.0.3 works on

• PC Windows 95, 98, NT 4.0: Microsoft Internet Explorer 4.0 and later. Netscape Navigator 3.04, Netscape Communicator 4.05 and later.
• Macintosh PowerPC: Netscape Navigator 3.04, Netscape Communicator 4.05 and later.
• SGI IRIX (release 0.9z) Netscape Navigator 3.0 and later.

Procedure for PC

The hardware and software requirements are:

• 16 megabytes RAM minimum
• 32 MB or more recommended
• VGA display minimum, 800x600 or better recommended
• Windows 95, 98, NT 4.0
• Netscape Navigator 3.04, Netscape Communicator 4.5 and later, or Microsoft Internet Explorer 4.01 and later

Chime is installed as a plug-in.

• If you had an older version, that one will be replaced by the new one.
• Close all other browsers who use Chime if you already installed it.
• Download directly the file "ch203w32.exe" or later from MDL, Information System Inc or download it from the download section of the MDL web-pages.
• A "file download" window asks if you want to save the file on the disk, click on OK.
• A "save as" window asks in what folder do you want to save it. Select the folder from the "save in" browser. Click on "save" (about 2Mbytes).
• Open the folder where you save this file and double-click on the ch203w32.exe icon to run the program installer.
• Fill the setup request and the program will be properly installed and the appropriate MIME types will be correctly defined. That means that further, all files downloaded from the web with a ".pdb" or ".ent" extension will launch automaticaly the Chime program in the selected browser. The molecule corresponding to the coordinates of the downloaded file or selected file in your own disk will be displayed as a "3-D active image" in the browser using a program from your own disk, executed on your own computer. You can choose to use Chime in Netscape or Explorer or both of them. If you select to use Chime only with one browser it is possible later to use an other molecule viewer with the other kind of browser without to change the MIME types and the name of the corresponding application every time you want to change a viewer.
• You are done.

If you need to change the MIME type (you do not have to if you just did the installation !) because you change your viewer program for Chime already installed:
for Internet Explorer

• Open Windows Explorer.
• Choose Views>Options (or View>Folder Options if you have Active Desktop enabled).
• Click the File Types tab to select it.
• Click the New Type button to add a new file type.
• Description of type : Protein Database RCSB
• File extension : pdb, ent, emb,embl
• Application to use: chemical/x-pdb

for Netscape Communicator

• Open Netscape.
• Choose Edit > Preferences >Navigator > Applications
• Click on the New Type button to add a new file type.
• Description of type : Protein Database RCSB
• File extension : pdb, ent
• MIME type : chemical/x-pdb
• Application to use : clik on browser and select your most recent Netscape icon
• Check the box to use the MIME as the outgoing default for this file extension.

The installer will place the following files on your system: Npchime.dll (in your Plug-ins folder) Npchime.zip (in your Plug-ins folder, used for LiveConnect [do not unzip this file]) Npchime.txt (in your Plug-ins folder, the readme for Chime) Chime203.isu (in your Plug-ins folder, used to uninstall Chime) Sculptapi.dll (in your Windows System folder, used for Sculpt).

If there is some troubleshootings go to the MDL FAQ-pages

Procedure for Mac

The hardware and software requirements are:

• PowerPC
• System 7.5 or later
• 16 megabytes RAM minimum, Connectix RamDoubler recommended or 32MB or more recommended
• 640x480 display minimum, 800x600 or better recommended
• Netscape Navigator 3.04 or Netscape Communicator 4.05 and later

Chime is installed as a plug-in for Netscape Communicator (not available for Internet explorer on Mac)

• If you had an older version, that one will be replaced by the new one.
• Close all other browsers who use Chime if you already installed it.
• Download directly the file "Chime_2.0a_Installer.hqx" or later from MDL, Information System Inc or download it from the download section of the MDL web-pages.
• A "file download" window asks if you want to save the file on the disk, click on OK.
• A "save as" window asks in what folder do you want to save it. Select the folder from the "save in" browser. Click on "save" (about 2Mbytes).
• Open the folder where you save this file and double-click on the "Chime_2.0a_Installer.hqx" icon to run the program installer.
• Fill the setup request and the program will be properly installed.
• Locate the Netscape Navigator application icon in the Netscape Navigator or Communicator Folder, single click on the Netscape Navigator application icon so it is highlighted, and open up the File->Get Info dialog and fix the minimum size should be at least 12000k and the preferred size at least 15000k.
• Open Netscape.
• Choose Edit > Preferences >Navigator > Applications
• Click on the New Type button to add a new file type.
• Description of type : Protein Database RCSB
• File extension : pdb, ent, emb, embl
• MIME type : chemical/x-pdb
• Application to use: clik on browser and select your most recent Netscape icon
• Check the box to use the MIME as the outgoing default for this file extension. That means that further, all files downloaded from the web with a ".pdb" or ".ent" extension will launch automaticaly the Chime program in the selected browser. The molecule corresponding to the coordinates of the downloaded file or selected file in your own disk will be displayed as a "3-D active image" in the browser using a program from your own disk, executed on your own computer. If you want to use later an other molecule viewer you will have to change the MIME types and the name of the corresponding application.
• You are done.

The installer will place the following files on your system: Chemscape Chime (in your Plug-ins folder) Chemscape Chime.zip (in your Plug-ins folder, used for LiveConnect [do not unzip this file])

If there is some troubleshootings (broken plug-in icon when viewing structures on a local disk...) go to the MDL FAQ-pages.

Chime is installed as a plug-in for Netscape Communicator (not available for Internet explorer on Mac)

• If you had an older version, that one will be replaced by the new one.
• Close all other browsers who use Chime if you already installed it.
• Download directly the file "chime_09z_sgi_8bit.tar.gz" or later from MDL, Information System Inc or download it from the download section of the MDL web-pages.
• A "file download" window asks if you want to save the file on the disk, click on OK.
• A "save as" window asks in what folder do you want to save it. Select the folder from the "save in" browser. Click on "save" (about 2Mbytes).
• Open the folder where you save this file and double-click on the chime_09z_sgi_8bit.tar.gz"Chime_2.0a_Installer.hqx" icon to run the program installer.
• Fill the setup request and the program will be properly installed.
• Locate the Netscape Navigator application icon in the Netscape Navigator or Communicator Folder, single click on the Netscape Navigator application icon so it is highlighted, and open up the File->Get Info dialog and fix the minimum size should be at least 12000k and the preferred size at least 15000k.
• Open Netscape.
• Choose Edit > Preferences > Navigator > Applications
• Click on the New Type button to add a new file type.
• Description of type : Protein Database RCSB
• File extension : pdb, ent, emb,embl
• MIME type : chemical/x-pdb
• Application to use: clik on browser and select your most recent Netscape icon
• Check the box to use the MIME as the outgoing default for this file extension. That means that further, all files downloaded from the web with a ".pdb" or ".ent" extension will launch automaticaly Chime in the selected browser. The molecule corresponding to the coordinates of the downloaded file or selected file in your own disk will be displayed as a "3-D active image" in the browser using a program from your own disk, executed on your own computer. If you want to use later an other molecule viewer you will have to change the MIME types and the name of the corresponding application.
• You are done.

A 1.0 version is in progress.

If there is some troubleshootings go to the MDL FAQ-pages.

How do you download and setup your browser to use VRML?

The Virtual Reality Modeling Language (VRML) is a standard language for describing interactive 3-D objects and worlds delivered across the Internet. Download a VRML plug-in for your station from the VRML repository maintained by the Web3D Consortium. See some examples, tutorials and development from the list .

How do you download and setup your browser to use Cn3D?

Cn3D is a viewing and analysis program from the NCBI structure group designed to allow linked sequence and structural display. You will find here the page to download and install the Structure Viewer version for PC, Mac and Unix workstations and to set up your browser..

[HomePage] [Sequence Index] [Sequence Analyser] [Mutations] [Evolution] [Tour-Tutorial] [Help]
[Structure Index] [Structure Analyzer] [Ligands] [Function][About] [Contact_us][Setup][Search] [Links]

Thierry Rose, PhD and Enrico Di Cera, MD
Department of Biochemistry and Molecular Biophysics
Washington University School of Medicine
Saint Louis, MO, U.S.A.